Greisler H P, Ellinger J, Schwarcz T H, Golan J, Raymond R M, Kim D U
Arch Surg. 1987 Jun;122(6):715-21. doi: 10.1001/archsurg.1987.01400180097019.
We analyzed histologic, ultrastructural, and functional characteristics of rabbit aortic conduits regenerated over absorbable polydioxanone prostheses. Twenty-eight polydioxanone-elicited prosthesis/tissue complexes harvested two weeks to 12 months following implantation were analyzed grossly; photographed; sectioned for light, scanning, and transmission electron microscopy; and studied for compliance, bursting strength, and prostacyclin and thromboxane metabolite contents. No aortic-related deaths or hemorrhages occurred. Smooth regenerated conduits without stenoses were seen in 27 of 28 specimens, with one small aneurysm. Transprosthetic myofibroblast migration and proliferation paralleled the kinetics of macrophage-mediated prosthetic dissolution, which was consequently delayed compared with polyglycolic acid prostheses. Confluent endothelial-like luminal surfaces were present after two weeks. Progressive inner capsular thickening ended after three months at 420 micron. Ex vivo compliance curves resembled arterial elasticity. Regenerated tissue withstood 1200 mm Hg of systolic pressure, and 6-keto-prostaglandin F1 alpha to thromboxane B2 ratios did not differ from normal control specimens.
我们分析了在可吸收聚二氧六环酮假体上再生的兔主动脉管道的组织学、超微结构和功能特征。对植入后两周至12个月收获的28个聚二氧六环酮引发的假体/组织复合物进行大体分析；拍照；切片用于光镜、扫描电镜和透射电镜检查；并研究其顺应性、破裂强度以及前列环素和血栓素代谢物含量。未发生与主动脉相关的死亡或出血。28个标本中有27个可见无狭窄的光滑再生管道，有一个小动脉瘤。经假体的肌成纤维细胞迁移和增殖与巨噬细胞介导的假体溶解动力学平行，因此与聚乙醇酸假体相比延迟。两周后出现融合的内皮样腔面。进行性内囊增厚在三个月后以420微米结束。体外顺应性曲线类似于动脉弹性。再生组织能承受1200毫米汞柱的收缩压，6-酮-前列腺素F1α与血栓素B2的比率与正常对照标本无差异。
