快速发展：可吸收合成血管移植物的转化设计。
Quickening: Translational design of resorbable synthetic vascular grafts.
机构信息
Meinig School of Biomedical Engineering, Cornell University, USA.
Meinig School of Biomedical Engineering, Cornell University, USA.
出版信息
Biomaterials. 2018 Aug;173:71-86. doi: 10.1016/j.biomaterials.2018.05.006. Epub 2018 May 5.
Abstract
Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research.
摘要
传统的组织工程血管移植物尚未得到广泛的临床应用。这些基于细胞或生物的产品规模化生产的困难阻碍了商业化。原位组织工程通过使用无细胞可吸收支架来避免这些物流挑战。植入后，支架被宿主细胞重塑。本文综述了无细胞合成血管移植物的科学和转化优势。调查了在其五十年技术发展过程中无细胞合成物的体内结果。最后，讨论了新兴的原则，强调了设计师的战略考虑，并确定了需要进一步研究的问题。
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