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Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9.

作者信息

Musch M W, Billah M M, Siegel M I

出版信息

Biochem Biophys Res Commun. 1987 May 14;144(3):1243-50. doi: 10.1016/0006-291x(87)91444-6.

DOI:10.1016/0006-291x(87)91444-6
PMID:3107564
Abstract

MC9 mast cells stimulated by a soluble (calcium ionophore A23187) or by an Fc epsilon-receptor agonist (IgE plus hapten) produce platelet activating factor (PAF). MC9 cells incorporate either exogenous [3H]acetic acid or [3H]lyso-PAF into PAF. PAF was identified by mobility on thin layer chromatography, platelet aggregatory activity inhibitable by known PAF antagonists, and by enzymatic modification. Quantified by aggregation of rabbit platelets, MC9 cells produce 6 pmoles PAF/10(6) cells. MC9 cells express acetyltransferase activity of 0.19 nmole/5 min-mg protein. Analysis of MC9 phospholipids by HPLC showed that MC9 cells contain large amounts of phosphatidylcholine (82 nmoles/10(7) cells) but contain little ether-linked phosphatidylcholine (4 nmoles/10(7) cells).

摘要

相似文献

1
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引用本文的文献

1
Interaction of platelet-activating factor with cultured guinea pig tracheal epithelial cells.血小板活化因子与培养的豚鼠气管上皮细胞的相互作用。
Biochem J. 1991 Jun 15;276 ( Pt 3)(Pt 3):593-8. doi: 10.1042/bj2760593.
2
Platelet-activating factor synthesis by peritoneal mast cells and its inhibition by two quinoline-based compounds.腹膜肥大细胞合成血小板活化因子及其受两种喹啉类化合物的抑制作用
Br J Pharmacol. 1992 Jan;105(1):87-92. doi: 10.1111/j.1476-5381.1992.tb14215.x.
3
Factors that influence the proportions of platelet-activating factor and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine synthesized by the mast cell.
影响肥大细胞合成血小板活化因子和1-酰基-2-乙酰基-sn-甘油-3-磷酸胆碱比例的因素。
Biochem J. 1992 Sep 1;286 ( Pt 2)(Pt 2):497-503. doi: 10.1042/bj2860497.