Cellesi C, Rossolini G M, Lusini P, Gerli R, Alessandrini C
Boll Ist Sieroter Milan. 1986;65(6):552-6.
Several enzyme activities in the enteric mucous membrane (maltase, lactase, leucineaminopeptidase) were assayed and intestinal epithelium ultrastructure was evaluated in mice treated with chloramphenicol, per os, in different doses (50 mg/Kg and 100 mg/Kg), for 10 days. Of the enzyme activities assayed, only leucineaminopeptidase was found to be significantly lower in treated animals than in controls. Enterocyte ultrastructure and mitochondrial morphometrical parameters were not found to be significantly modified in treated animals.
对经口给予不同剂量（50毫克/千克和100毫克/千克）氯霉素处理10天的小鼠，测定了肠黏膜中的几种酶活性（麦芽糖酶、乳糖酶、亮氨酸氨肽酶），并评估了肠上皮超微结构。在所测定的酶活性中，仅发现处理组动物的亮氨酸氨肽酶显著低于对照组。未发现处理组动物的肠上皮细胞超微结构和线粒体形态计量学参数有显著改变。
