前列腺素代谢与眼压
Prostaglandin metabolism and intraocular pressure.
作者信息
Naveh-Floman N, Belkin M
出版信息
Br J Ophthalmol. 1987 Apr;71(4):254-6. doi: 10.1136/bjo.71.4.254.
The plasma lipid alterations characteristic of essential fatty acid deficiency (EFAD) generally appear one to two weeks after the initiation of fat free parenteral nutritional (PN), and may be associated with a reduction in prostaglandin (PG) formation. In the present study the relationship between exclusion of fat from the diet and changes in intraocular pressure (IOP) and PGE2 plasma levels were studied in 28 patients. The results indicated that three weeks after the omission of dietary fat a significant reduction in IOP levels occurred which persisted throughout the follow-up period of 7 (SD 1.2) weeks. Plasma PGE2 levels were also significantly reduced in patients on fat free PN for three weeks as compared with levels measured while patients were on a fat containing diet. This clinical observation is not yet understood and might be related to changes exerted by fatty acid deficiency.
必需脂肪酸缺乏（EFAD）所特有的血浆脂质改变通常在开始无脂肠外营养（PN）一至两周后出现，并且可能与前列腺素（PG）生成减少有关。在本研究中，对28例患者进行了饮食中脂肪排除与眼压（IOP）变化及血浆PGE2水平之间关系的研究。结果表明，在饮食中去除脂肪三周后，IOP水平显著降低，且在7（标准差1.2）周的随访期内持续存在。与患者食用含脂肪饮食时测得的水平相比，接受三周无脂PN治疗的患者血浆PGE2水平也显著降低。这一临床观察结果尚不清楚，可能与脂肪酸缺乏所产生的变化有关。
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