从Ipomoea nil 的种子中分离得到的新的十八烷衍生物。

New octadecanoid derivatives from the seeds of Ipomoea nil.

机构信息

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China; School of Biological Science and Technology, University of Jinan, Jinan 250022, China.

School of Biological Science and Technology, University of Jinan, Jinan 250022, China.

出版信息

Chin J Nat Med. 2019 Apr;17(4):303-307. doi: 10.1016/S1875-5364(19)30034-2.

DOI:10.1016/S1875-5364(19)30034-2

PMID:31076134

Abstract

Four new octadecanoid derivatives (1-4) including a pair of enantiomers (1/2), along with 12 known analogues (5-16), were isolatedfrom the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better α-glucosidase inhibitory activity than the positive control acarbose (IC 167.7 ± 1.55 μmol·L), with IC of 92.73 ± 3.12 and 11.39 ± 2.18μmol·L, respectively.

摘要

从Ipomoea nil 种子中分离得到了 4 种新的十八烷酸衍生物（1-4），包括一对对映异构体（1/2），以及 12 种已知类似物（5-16）。通过详细的光谱分析和与结构相关化合物的报道数据进行比较，确定了它们的结构，通过原位二钼 ECD 方法确定了 1 和 2 的绝对构型。我们的生物测定结果表明，这些分离物没有表现出 ABTS 自由基清除活性，而 10 和 13 对α-葡萄糖苷酶的抑制活性比阳性对照阿卡波糖（IC 167.7 ± 1.55 μmol·L）更好，IC 分别为 92.73 ± 3.12 和 11.39 ± 2.18μmol·L。