Choi Janggyoo, Yoon Kee Dong, Kim Jinwoong
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 08826, Republic of Korea.
College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Bioorg Med Chem Lett. 2018 Feb 1;28(3):476-481. doi: 10.1016/j.bmcl.2017.12.014. Epub 2017 Dec 8.
Three novel butyrolactones (1-3) and butanoates (4-6), namely taraxiroside A-F, were isolated from Taraxacum officinale along with twenty-two known compounds (7-28). Their chemical structures were elucidated by interpretation of spectroscopic data and comparison with those of literatures. All isolates were evaluated for their α-glucosidase inhibitory activities. Novel compounds 1-6 (IC 145.3-181.3 μM) showed inhibitory activities similar to that of acarbose (IC 179.9 μM). Compound 7 and 12 were the most potent inhibitor with IC values of 61.2 and 39.8 μM respectively. Compounds 2 and 12 showed as mixed-type inhibition, whereas compound 7 and acarbose showed competitive inhibition.
从蒲公英中分离出三种新型丁内酯（1-3）和丁酸酯（4-6），即蒲公英苷A-F，同时还分离出二十二种已知化合物（7-28）。通过光谱数据解析并与文献数据对比，阐明了它们的化学结构。对所有分离物进行了α-葡萄糖苷酶抑制活性评估。新型化合物1-6（IC 145.3-181.3μM）表现出与阿卡波糖（IC 179.9μM）相似的抑制活性。化合物7和12是最有效的抑制剂，IC值分别为61.2和39.8μM。化合物2和12表现为混合型抑制，而化合物7和阿卡波糖表现为竞争性抑制。
