《满江红（一种绿色水生植物）对餐后血糖反应的影响：一项随机交叉对照试验》。

The Effect of Mankai, a Green Aquatic Plant, on Postprandial Glycemic Response: A Randomized Crossover Controlled Trial.

机构信息

Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Soroka University Medical Center, Beer Sheva, Israel.

出版信息

Diabetes Care. 2019 Jul;42(7):1162-1169. doi: 10.2337/dc18-2319. Epub 2019 May 10.

DOI:10.2337/dc18-2319

PMID:31076421

Abstract

OBJECTIVE

To compare the postprandial and overnight glycemic response using a novel green aquatic plant thought to provide a dietary source for high-quality protein, with an iso-carbohydrate/protein/caloric dairy shake.

RESEARCH DESIGN AND METHODS

This is a randomized controlled crossover trial among 20 abdominally obese participants (age 51.4 years; fasting plasma glucose 110.9 mg/dL), who were allocated to replace dinner with either, first, a green shake containing duckweed (Mankai: specific-strain) or an iso-carbohydrate/protein/calorie yogurt shake. A 2-week flash glucose-monitoring system was used to assess postmeal glucose dynamics (6 net administration days; 97 observation days in total). We further obtained from each participant dietary/daily activity/satiety scale/sleep logs. Participants were recruited from the green-Mediterranean diet arm of the 18-month Dietary Intervention Randomized Controlled Trial-Polyphenols Unprocessed (DIRECT-PLUS) study.

RESULTS

Mankai elicited a lower postprandial glucose peak compared with yogurt (∆peak = 13.4 ± 9.2 vs. 19.3 ± 15.1 mg/dL; = 0.044), which occurred later (77.5 ± 29.2 vs. 59.2 ± 28.4 min; = 0.037) and returned faster to baseline glucose levels (135.8 ± 53.1 vs. 197.5 ± 70.2 min; = 0.012). The mean post-net incremental area under the curve (netAUC) was lower with up to 60 and 180 min (netAUC 60 min: 185.1 ± 340.1 vs. 441.4 ± 336.5 mg/dL/min, = 0.005; netAUC 180 min: 707.9 ± 1,428.5 vs. 1,576.6 ± 1,810.1 mg/dL/min, = 0.037). A -based shake replacing dinner resulted in lower next-morning fasting glucose levels (83.2 ± 0.8 vs. 86.6 ± 13 mg/dL; = 0.041). Overall, postprandial glucose levels from the shake administration until the next morning were lower in the Mankai green shake compared with the yogurt shake ( < 0.001). Overnight sleep duration was similar (378.2 ± 22.4 vs. 375.9 ± 28.4 min; = 0.72), and satiety rank was slightly higher for the shake compared with the yogurt shake (7.5 vs. 6.5; = 0.035).

CONCLUSIONS

Mankai duckweed may serve as an emerging alternative plant protein source with potential beneficial postprandial glycemic effects.

摘要

目的

比较新型绿色水生植物（被认为是高质量蛋白质的饮食来源）与等碳水化合物/蛋白质/热量乳清蛋白奶昔的餐后和夜间血糖反应。

研究设计和方法

这是一项在 20 名腹部肥胖参与者（年龄 51.4 岁；空腹血糖 110.9mg/dL）中进行的随机对照交叉试验，参与者被分配用含有浮萍（万凯：特定菌株）的绿色奶昔或等碳水化合物/蛋白质/热量酸奶奶昔代替晚餐。使用为期 2 周的实时血糖监测系统来评估餐后血糖动态（6 个净管理日；总共 97 个观察日）。我们还从每位参与者那里获得了饮食/日常活动/饱腹感量表/睡眠日志。参与者是从为期 18 个月的饮食干预随机对照试验-多酚未加工（DIRECT-PLUS）研究的绿色-地中海饮食组招募的。

结果

与酸奶相比，万凯的餐后血糖峰值较低（∆峰值=13.4±9.2 vs.19.3±15.1mg/dL；=0.044），且出现较晚（77.5±29.2 vs.59.2±28.4min；=0.037），并更快地恢复到基线血糖水平（135.8±53.1 vs.197.5±70.2min；=0.012）。直至 60 和 180 分钟时，净增量曲线下面积（netAUC）的平均餐后增量较低（netAUC 60min：185.1±340.1 vs.441.4±336.5mg/dL/min，=0.005；netAUC 180min：707.9±1,428.5 vs.1,576.6±1,810.1mg/dL/min，=0.037）。用基于浮萍的奶昔代替晚餐会导致次日清晨空腹血糖水平降低（83.2±0.8 vs.86.6±13mg/dL；=0.041）。总体而言，与酸奶奶昔相比，万凯绿色奶昔的餐后血糖水平直至次日清晨更低（<0.001）。夜间睡眠时间相似（378.2±22.4 vs.375.9±28.4min；=0.72），并且与酸奶奶昔相比，饱腹感评分略高（7.5 分 vs.6.5 分；=0.035）。