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1
Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets.在肺癌中操纵肿瘤抑制蛋白 Rb 揭示了可能的药物靶点。
Nature. 2019 May;569(7756):343-344. doi: 10.1038/d41586-019-01319-y.
2
Inhibition of retinoblastoma tumor suppressor activity by RNA interference in lung cancer lines.通过RNA干扰在肺癌细胞系中抑制视网膜母细胞瘤肿瘤抑制活性。
Ann Thorac Surg. 2006 Jul;82(1):249-53. doi: 10.1016/j.athoracsur.2006.02.033.
3
Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group.非小细胞肺癌中视网膜母细胞瘤易感基因的失活。肺癌研究组。
Oncogene. 1993 Jul;8(7):1913-9.
4
[Cell cycle, tumor suppressor genes and lung cancers].[细胞周期、肿瘤抑制基因与肺癌]
Rev Mal Respir. 1998 Sep;15(4):461-6.
5
Relations of tumor suppressor gene p16 and RB to early diagnosis of lung cancer.肿瘤抑制基因p16和RB与肺癌早期诊断的关系。
Zhonghua Wai Ke Za Zhi. 2000 Dec;38(12):885-9.
6
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.间皮瘤和肺癌中RB相关基因家族及SV40大T抗原的蛋白表达
Oncogene. 2000 Sep 21;19(40):4632-9. doi: 10.1038/sj.onc.1203815.
7
RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer.RB与细胞周期蛋白依赖性激酶通路：明确肺癌中RB缺失与p16缺失的区别
Oncogene. 2002 Oct 7;21(45):6908-14. doi: 10.1038/sj.onc.1205834.
8
[Relationship between tumor suppressor gene p16 and Rb and early diagnosis of lung cancers].
Zhonghua Wai Ke Za Zhi. 2000 Jul;38(7):537-41, 30.
9
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.视网膜母细胞瘤基因Rb及其家族成员p130可抑制致癌性K-Ras诱导的肺腺癌。
Oncogene. 2009 Mar 12;28(10):1393-9. doi: 10.1038/onc.2008.491. Epub 2009 Jan 19.
10
[Synergistic effect of the expression of p16INK4 gene and retinoblastoma gene in lung cancer].
Yi Chuan Xue Bao. 2001;28(7):601-5.

引用本文的文献

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The regulatory landscape of retinoblastoma: a pathway analysis perspective.视网膜母细胞瘤的监管格局：从通路分析角度看
R Soc Open Sci. 2022 May 18;9(5):220031. doi: 10.1098/rsos.220031. eCollection 2022 May.
2
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin.CRISPR/Cas9 文库筛选发现，甲基化 PKP2 通过稳定 β-连环蛋白成为肺癌放射抵抗的关键驱动因素。
Oncogene. 2021 Apr;40(16):2842-2857. doi: 10.1038/s41388-021-01692-x. Epub 2021 Mar 19.
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A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers.一种新型 CDK2/9 抑制剂 CYC065 导致非整倍体癌症的后期灾难和抑制增殖、肿瘤发生和转移。
Mol Cancer Ther. 2021 Mar;20(3):477-489. doi: 10.1158/1535-7163.MCT-19-0987. Epub 2020 Dec 4.
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Identifying CpG methylation signature as a promising biomarker for recurrence and immunotherapy in non-small-cell lung carcinoma.鉴定 CpG 甲基化特征作为非小细胞肺癌复发和免疫治疗的有前途的生物标志物。
Aging (Albany NY). 2020 Jul 28;12(14):14649-14676. doi: 10.18632/aging.103517.

本文引用的文献

1
CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought.CDK4/6 抑制剂：作用机制可能不像以前认为的那么简单。
Cancer Cell. 2018 Jul 9;34(1):9-20. doi: 10.1016/j.ccell.2018.03.023. Epub 2018 May 3.
2
Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.Rb1和Trp53协同作用以抑制前列腺癌的谱系可塑性、转移和抗雄激素耐药性。
Science. 2017 Jan 6;355(6320):78-83. doi: 10.1126/science.aah4199.
3
RB1: a prototype tumor suppressor and an enigma.RB1：一种肿瘤抑制原型与一个谜团。
Genes Dev. 2016 Jul 1;30(13):1492-502. doi: 10.1101/gad.282145.116.
4
Crosstalk between stem cell and cell cycle machineries.干细胞与细胞周期机制之间的相互作用。
Curr Opin Cell Biol. 2015 Dec;37:68-74. doi: 10.1016/j.ceb.2015.10.001. Epub 2015 Nov 11.
5
Deciphering the retinoblastoma protein phosphorylation code.解析视网膜母细胞瘤蛋白磷酸化密码。
Trends Biochem Sci. 2013 Jan;38(1):12-9. doi: 10.1016/j.tibs.2012.10.007. Epub 2012 Dec 3.
6
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma.未分化多形性肉瘤与胚胎性横纹肌肉瘤之间意外关系的证据。
Cancer Cell. 2011 Feb 15;19(2):177-91. doi: 10.1016/j.ccr.2010.12.023.
7
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.视网膜母细胞瘤基因Rb及其家族成员p130可抑制致癌性K-Ras诱导的肺腺癌。
Oncogene. 2009 Mar 12;28(10):1393-9. doi: 10.1038/onc.2008.491. Epub 2009 Jan 19.
8
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.细胞外信号调节激酶1/2（ERK1/2）丝裂原活化蛋白激酶途径作为G1期到S期转换的主要调节因子。
Oncogene. 2007 May 14;26(22):3227-39. doi: 10.1038/sj.onc.1210414.
9
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells.组成型MEK/MAPK激活导致人乳腺癌细胞中p27（Kip1）失调和抗雌激素耐药。
J Biol Chem. 2001 Nov 2;276(44):40888-95. doi: 10.1074/jbc.M106448200. Epub 2001 Aug 29.

在肺癌中操纵肿瘤抑制蛋白 Rb 揭示了可能的药物靶点。

Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets.

出版信息

Nature. 2019 May;569(7756):343-344. doi: 10.1038/d41586-019-01319-y.

DOI:10.1038/d41586-019-01319-y
PMID:31076732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7197376/
Abstract

Tumours often become resistant to treatment, but how this occurs is poorly understood. An analysis of how the protein Rb affects tumour growth and the response to therapy might cast light on the problem.

摘要

肿瘤常常对治疗产生耐药性，但人们对此知之甚少。分析蛋白 Rb 如何影响肿瘤生长和对治疗的反应，可能有助于揭示这个问题。