Rogers D, Lees A J, Smith E, Trimble M, Stern G M
Brain. 1987 Jun;110 ( Pt 3):761-76. doi: 10.1093/brain/110.3.761.
Thirty newly diagnosed patients with Parkinson's disease and 30 patients with primary depressive illness showed slowing of response on a computerized digit symbol substitution test when compared with 30 matched normal control subjects. Significant slowing was related, in the parkinsonian patients, to structural brain disorder and affective impairment and, in the depressed patients, to motor impairment. A second computerized test, cognitively simpler but requiring the same motor response, was also administered to each subject. Both cognitive and motor slowing seemed to contribute to slowing of response in the digit symbol test in both parkinsonian and depressed patients. The tests were repeated after about six months in 12 subjects from each group. The parkinsonian patients, on dopaminergic treatment, showed neither significant change in motor or affective impairment, nor improvement in response time for the digit symbol test, but change in response time was related to change in depression rating. The depressed patients, on conventional treatment, showed significant improvement in both affective and motor impairment and improvement in response time for the digit symbol test, due to improvement in cognitive slowing. It is proposed that bradyphrenia in Parkinson's disease and psychomotor retardation in depressive illness are closely related, and that impairment of dopaminergic systems may be involved in both.
与30名相匹配的正常对照受试者相比，30名新诊断的帕金森病患者和30名原发性抑郁症患者在计算机化数字符号替代测试中反应减慢。在帕金森病患者中，显著的反应减慢与脑结构障碍和情感障碍有关；在抑郁症患者中，则与运动障碍有关。还对每位受试者进行了第二项计算机化测试，该测试认知要求较低，但需要相同的运动反应。在帕金森病患者和抑郁症患者中，认知和运动减慢似乎都导致了数字符号测试中的反应减慢。每组12名受试者在大约六个月后重复进行测试。接受多巴胺能治疗的帕金森病患者，运动或情感障碍均无显著变化，数字符号测试的反应时间也无改善，但反应时间的变化与抑郁评分的变化有关。接受传统治疗的抑郁症患者，情感和运动障碍均有显著改善，数字符号测试的反应时间也有所改善，这是由于认知减慢得到了改善。有人提出，帕金森病中的思维迟缓与抑郁症中的精神运动迟缓密切相关，多巴胺能系统受损可能与两者都有关。
