Department of Psychiatry and National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.
Psychiatry Clin Neurosci. 2019 Aug;73(8):466-475. doi: 10.1111/pcn.12860. Epub 2019 Jun 5.
Autism spectrum disorder is a neurodevelopmental condition in which affected individuals have difficulties while interacting and communicating socially, and repetitive behaviors. It has a multifactorial etiology. Various risk factors, including genetic and environmental influences, have been explored while trying to understand its causation. As older evidence was suggestive of a high heritability, a majority of research focused on finding the underlying genetic causes of autism. Due to these efforts, there have been advances in the knowledge of some of the genetic factors associated with autism. But a recent trend also shows an increasing interest in exploration of various potential environmental triggers. These efforts have brought us closer to understanding the elusive disorder more so than ever before. The current review discusses the recent trends in research exploring the etiopathogenesis of autism spectrum disorder.
自闭症谱系障碍是一种神经发育障碍,受影响的个体在社交互动和沟通方面存在困难,并且存在重复行为。它具有多因素病因。为了了解其病因,已经探讨了各种风险因素,包括遗传和环境影响。由于旧的证据表明遗传率很高,因此大多数研究都集中在寻找自闭症的潜在遗传原因上。由于这些努力,我们对一些与自闭症相关的遗传因素的了解有所进展。但是,最近的趋势也显示出越来越多的人对探索各种潜在环境触发因素的兴趣。这些努力使我们比以往任何时候都更能理解这种难以捉摸的疾病。本综述讨论了探索自闭症谱系障碍病因发病机制的最新研究趋势。