Department of Physical and Chemical Sciences, University of L'Aquila, L'Aquila, Italy.
Department of Industrial and Information Engineering and Economics, University of L'Aquila, L'Aquila, Italy.
J Biomed Mater Res A. 2019 Sep;107(9):2026-2039. doi: 10.1002/jbm.a.36716. Epub 2019 May 18.
In this study, we examined three different syntheses of hydroxyapatite (HAp) and graphene oxide-hydroxyapatite (GO-HAp) composites with a GO content of 9, 33, and 43% wt. The materials were prepared from various precursors of calcium and phosphate ions, using an in situ synthesis method, with mild conditions to avoid reducing the GO. In situ bonding technology proposed that calcium ions bond with GO at first and then HAp nanoflakes in situ grow on GO sheets, forming GO-HAp nanocomposite. The aim of the present work was to analyze the differences due to the use of different starting reagents and verify, with the addition of increasing amounts of GO, the changes in morphology, crystallinity, and solubility of the obtained HAp composites. Detailed structural and morphological characterization studies of the composites were carried out using scanning electron microscopy, energy dispersive X-ray spectrometry, X-ray powder diffraction, Raman spectroscopy, and Fourier transform infrared spectroscopy. We found that GO sheets act as a nucleation site for HAp mineralization, but we observed a loss of the crystallographic order due to the intercalation of the graphenic sheets between the HAp particles.
在这项研究中，我们研究了三种不同的羟基磷灰石（HAp）和氧化石墨烯-羟基磷灰石（GO-HAp）复合材料的合成方法，其中 GO 的含量分别为 9%、33%和 43%wt。这些材料是由不同的钙和磷酸盐离子前体制备而成的，采用原位合成方法，条件温和，以避免还原 GO。原位键合技术提出，钙离子首先与 GO 键合，然后 HAp 纳米片在 GO 片上原位生长，形成 GO-HAp 纳米复合材料。本工作的目的是分析使用不同起始试剂的差异，并验证随着 GO 含量的增加，所得到的 HAp 复合材料的形貌、结晶度和溶解度的变化。使用扫描电子显微镜、能量色散 X 射线光谱仪、X 射线粉末衍射、拉曼光谱和傅里叶变换红外光谱对复合材料进行了详细的结构和形态表征研究。我们发现 GO 片作为 HAp 矿化的成核位点，但由于石墨片层插在 HAp 颗粒之间，导致结晶度有序性丧失。
