Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.
Clin Gastroenterol Hepatol. 2020 Mar;18(3):736-738. doi: 10.1016/j.cgh.2019.04.066. Epub 2019 May 8.
Cytomegalovirus (CMV) can infect multiple areas of the gastrointestinal tract, most commonly the esophagus and colon. CMV esophagitis is the third leading cause of infectious esophagitis, after Candida and herpes simplex virus. It occurs predominantly in immunocompromised hosts such as patients with human immunodeficiency virus (HIV) and is considered an acquired immunodeficiency syndrome (AIDS) defining illness. However, more recent case reports suggest that this disease may also affect the non-HIV immunosuppressed patient population. The aim of this study was to reevaluate predictors for development of CMV esophagitis in the post highly active antiretroviral therapy era and describe clinical and endoscopic features of CMV esophagitis as well as patient outcomes from a large tertiary care center.
巨细胞病毒（CMV）可感染胃肠道的多个部位，最常见于食管和结肠。CMV 食管炎是继念珠菌和单纯疱疹病毒之后引起感染性食管炎的第三大常见病因。它主要发生于免疫功能低下的宿主，如人类免疫缺陷病毒（HIV）患者，被认为是获得性免疫缺陷综合征（AIDS）的一种确定疾病。然而，最近的病例报告表明，这种疾病也可能影响非 HIV 免疫抑制患者人群。本研究旨在重新评估在高效抗逆转录病毒治疗时代后发生 CMV 食管炎的预测因素，并描述来自大型三级护理中心的 CMV 食管炎的临床和内镜特征以及患者结局。
