Nigro N D, Bull A W, Boyd M E
Cancer Lett. 1987 May;35(2):153-8. doi: 10.1016/0304-3835(87)90039-5.
The effect of the duration and sequence of inhibition of intestinal tumor formation in rats was studied to determine whether part time inhibition has any value. Four groups of male Sprague-Dawley rats were given 8 weekly s.c. injections of azoxymethane (AOM) 8 mg/rat. Three groups were given the inhibitor, difluoromethylornithine (DFMO) in the drinking water; one for the entire 26 weeks of the study, one for the first 13 weeks only, and one for the last 13 weeks. A control group was not given the inhibitor. While the continuous treatment group developed the least number of tumors per rat (1.5 vs. 5 for controls), still both groups given the inhibitor for just 13 weeks also developed fewer tumors than controls 5 vs. 3.2 (early treatment) and 5 vs. 2.8 (late treatment). These results show that part time inhibition, including its late application, does reduce intestinal tumor formation in rats.
研究了抑制大鼠肠道肿瘤形成的持续时间和顺序的影响，以确定部分时间抑制是否有任何价值。四组雄性斯普拉格-道利大鼠每周皮下注射8毫克/只的偶氮甲烷（AOM），共注射8周。三组大鼠在饮用水中给予抑制剂二氟甲基鸟氨酸（DFMO）；一组在整个26周的研究期间给药，一组仅在最初13周给药，一组在最后13周给药。对照组不给予抑制剂。虽然持续治疗组每只大鼠发生的肿瘤数量最少（对照组为5个，该组为1.5个），但仅给药13周的两组大鼠发生的肿瘤也比对照组少，早期治疗组为3.2个（对照组为5个），晚期治疗组为2.8个（对照组为5个）。这些结果表明，部分时间抑制，包括晚期应用，确实能减少大鼠肠道肿瘤的形成。
