Soullier B K, Wilson P S, Nigro N D
Cancer Lett. 1981 May;12(4):343-8. doi: 10.1016/0304-3835(81)90177-4.
The effects of selenium supplementation on azoxymethane-induced intestinal cancer were studied in male Sprague- Dawley rats given 8 weekly injections of azoxymethane (8 mg/kg body wt), and fed a 30% beef fat diet. Selenium-supplemented groups received 8 ppm H2SeO3 in drinking water. Blood selenium levels of supplemented rats increased rapidly the first 9 weeks of the experiment, followed by a plateau significantly higher than that for non-selenium controls. There was a significantly increase in liver and intestinal selenium levels in supplemented groups. The average number of intestinal tumors was 6.5 in the control group, and 3.1 in the selenium-supplemented group. There was a significant reduction in tumor incidence in the proximal half of the colon of selenium-treated rats. There was also increased concentration of tissue selenium in the proximal half of the colon of these rats.
在给予雄性斯普拉格-道利大鼠每周8次注射氧化偶氮甲烷（8毫克/千克体重）并喂食30%牛肉脂肪饮食的情况下，研究了补充硒对氧化偶氮甲烷诱导的肠道癌的影响。补充硒的组在饮用水中添加8 ppm的亚硒酸。在实验的前9周，补充硒的大鼠血液中的硒水平迅速升高，随后趋于平稳，且显著高于未补充硒的对照组。补充硒的组肝脏和肠道中的硒水平显著增加。对照组肠道肿瘤的平均数量为6.5个，补充硒的组为3.1个。在接受硒治疗的大鼠结肠近端，肿瘤发生率显著降低。这些大鼠结肠近端的组织硒浓度也有所增加。
