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Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.

作者信息

Goettel Jeremy A, Kotlarz Daniel, Emani Rohini, Canavan James B, Konnikova Liza, Illig David, Frei Sandra M, Field Michael, Kowalik Matthew, Peng Kaiyue, Gringauz Jordan, Mitsialis Vanessa, Wall Sarah M, Tsou Amy, Griffith Alexandra E, Huang Ying, Friedman Joshua R, Towne Jennifer E, Plevy Scott E, O'Hara Hall Aisling, Snapper Scott B

机构信息

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

出版信息

Cell Mol Gastroenterol Hepatol. 2019;8(2):193-195. doi: 10.1016/j.jcmgh.2019.05.001. Epub 2019 May 9.

DOI:10.1016/j.jcmgh.2019.05.001
PMID:
31078723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6661391/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2caa/6661391/925f733ace98/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2caa/6661391/0e682588ed7d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2caa/6661391/925f733ace98/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2caa/6661391/0e682588ed7d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2caa/6661391/925f733ace98/gr2.jpg

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Clin Immunol. 2017 Jun;179:47-53. doi: 10.1016/j.clim.2017.02.001. Epub 2017 Feb 14.
2
Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.低剂量白细胞介素-2 治疗可选择性调节系统性红斑狼疮患者的 CD4(+) T 细胞亚群。
Nat Med. 2016 Sep;22(9):991-3. doi: 10.1038/nm.4148. Epub 2016 Aug 8.
3
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases.
微生物群、饮食与调节性T细胞在炎症性肠病肠道屏障保护中的相互作用。
Front Microbiol. 2023 Dec 1;14:1291724. doi: 10.3389/fmicb.2023.1291724. eCollection 2023.
4
Emerging Therapies for Ulcerative Colitis: Updates from Recent Clinical Trials.溃疡性结肠炎的新兴疗法：近期临床试验的最新进展
Clin Exp Gastroenterol. 2023 Aug 17;16:147-167. doi: 10.2147/CEG.S375969. eCollection 2023.
5
The role of group 3 innate lymphoid cell in intestinal disease.固有淋巴细胞 3 群在肠道疾病中的作用。
Front Immunol. 2023 Apr 14;14:1171826. doi: 10.3389/fimmu.2023.1171826. eCollection 2023.
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