State Key Laboratory of Cell Biology, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China; CAS Key Laboratory of Systems Biology, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.
State Key Laboratory of Cell Biology, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China; CAS Key Laboratory of Systems Biology, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.
Cancer Lett. 2019 Aug 10;457:20-27. doi: 10.1016/j.canlet.2019.04.039. Epub 2019 May 9.
Organoid technology has been remarkably improved over the last decade. Various organoids have been derived from different types of tissues and recapitulate their organ-specific gene expression signatures, particular tissue spatial structures and functions of their original tissue. The patient-derived organoids (PDOs) have been used to elucidate crucial scientific questions, including the relationships between genetic/epigenetic alterations and drug responses, cell plasticity during disease progressions, and mechanisms of drug resistances. With the great expectations, PDOs will be widely used to facilitate the personalized medical decisions, which have the potential to profoundly improve patient outcomes. In this review, we will discuss the developmental details, current achievements, applications and challenges of organoid technology in precision cancer medicine.
器官类器官技术在过去十年中取得了显著的进步。各种器官类器官已从不同类型的组织中分离出来，并重现了其器官特异性基因表达特征、特定组织的空间结构和其原始组织的功能。患者来源的类器官（PDO）已被用于阐明关键的科学问题，包括遗传/表观遗传改变与药物反应之间的关系、疾病进展过程中的细胞可塑性以及耐药机制。有了这些巨大的期望，PDO 将被广泛用于促进个性化医疗决策，这有可能极大地改善患者的预后。在这篇综述中，我们将讨论精准癌症医学中器官类器官技术的发展细节、当前成就、应用和挑战。
