Division of Prenatal Diagnostics and Gynecologic Ultrasound, Women's Hospital, Basel University Hospital, Basel, Switzerland.
Division of Neuro- and Developmental Paediatrics, University Children's Hospital Basel (UKBB), Basel, Switzerland.
Childs Nerv Syst. 2020 Feb;36(2):393-399. doi: 10.1007/s00381-019-04189-x. Epub 2019 May 12.
Foetal ventriculomegaly (VM) is one of the most commonly diagnosed brain abnormalities. The aims of this study were to assess cases with isolated VM, describe the prenatal course and assess short- and long-term follow-up at the age of 2 years.
We performed a retrospective analysis from our prenatal data base and included all children that were prenatally diagnosed with VM in our unit between 2008 and 2013 (n = 250). Prenatal management, postnatal outcome and neurologic development at the age of 2 years were evaluated.
A total of 106 children were born at our institution and were diagnosed prenatally with isolated borderline VM. A total of 1.9% (n = 2/106) was transferred to the neonatal unit. A total of 0.9% (n = 1/106) showed abnormal findings in postnatal brain ultrasound. A total of 1.9% (n = 2/106) showed mild neurologic abnormalities after birth, but none had to be seen by a neuropediatrician. At the follow-up at 2 years, 2.5% (n = 1/40) had an insertion of a shunt.
Based on our analysis, the majority of isolated borderline VM do not show short- or long-term neurological abnormalities. However, all cases of VM should be referred to a detailed prenatal ultrasound exam by a specialist.
胎儿脑室扩张（VM）是最常诊断出的脑部异常之一。本研究的目的是评估单纯 VM 病例，描述产前病程，并评估 2 岁时的短期和长期随访结果。
我们对来自我们的产前数据库进行了回顾性分析，纳入了 2008 年至 2013 年期间在我院被产前诊断为 VM 的所有儿童（n=250）。评估了产前管理、产后结局和 2 岁时的神经发育情况。
共有 106 名儿童在我院出生，产前诊断为单纯边缘性 VM。共有 1.9%（n=2/106）被转至新生儿病房。共有 0.9%（n=1/106）在产后脑超声检查中发现异常。共有 1.9%（n=1/106）在出生后出现轻度神经功能异常，但均无需神经科医生就诊。在 2 岁时的随访中，2.5%（n=1/40）需要植入分流管。
根据我们的分析，大多数单纯边缘性 VM 不会出现短期或长期神经功能异常。然而，所有 VM 病例均应转由专家进行详细的产前超声检查。
