Thongchaivetcharat Kusuma, Jenjob Ratchapol, Seidi Farzad, Crespy Daniel
Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong 21210, Thailand.
Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong 21210, Thailand.
Carbohydr Polym. 2019 Aug 1;217:217-223. doi: 10.1016/j.carbpol.2019.04.023. Epub 2019 Apr 9.
Controlled release of payloads such as drugs or corrosion inhibitors from nanocapsules is a prerequisite for their utilization. Indeed, premature leaching and contamination of the environment can be avoided. Herein, we investigate the pH-dependence of release kinetics of corrosion inhibitors from nanocapsules. Nanocapsules are formed by interfacial crosslinking of dextran derivatives in inverse miniemulsion and subsequently re-dispersed in aqueous solutions. Release kinetics are highly dependent on pH value and can be explained by a complex interplay involving swelling of nanocapsules shell, solubility of corrosion inhibitors, and electrostatic interactions between payloads and the shell.
从纳米胶囊中控制释放药物或缓蚀剂等负载物是其得以应用的前提条件。事实上，这样可以避免过早的浸出和环境污染。在此，我们研究了纳米胶囊中缓蚀剂释放动力学的pH依赖性。纳米胶囊通过反相微乳液中葡聚糖衍生物的界面交联形成，随后重新分散于水溶液中。释放动力学高度依赖于pH值，并且可以通过涉及纳米胶囊壳层溶胀、缓蚀剂溶解度以及负载物与壳层之间静电相互作用的复杂相互作用来解释。
