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Electroencephalography-guided anaesthetic administration does not impact postoperative delirium among older adults undergoing major surgery: an independent discussion of the ENGAGES trial.脑电图引导下的麻醉给药对接受大手术的老年人术后谵妄无影响：ENGAGES试验的独立讨论
Br J Anaesth. 2019 Aug;123(2):112-117. doi: 10.1016/j.bja.2019.03.016. Epub 2019 May 10.
2
Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: a pragmatic, randomised clinical trial.脑电图引导麻醉减轻老年综合征（ENGAGES）研究方案：一项实用的随机临床试验。
BMJ Open. 2016 Jun 15;6(6):e011505. doi: 10.1136/bmjopen-2016-011505.
3
Against dissing BIS. Comment on 'An independent discussion of the ENGAGES trial' (Br J Anaesth 2019; 123:112-7).反对诋毁脑电双频指数。对《ENGAGES试验的独立讨论》的评论（《英国麻醉学杂志》2019年；123:112 - 117）
Br J Anaesth. 2019 Oct;123(4):e488-e489. doi: 10.1016/j.bja.2019.06.022. Epub 2019 Jul 30.
4
Electroencephalography-Guided Anesthetic Administration and Postoperative Delirium.脑电图引导下的麻醉给药与术后谵妄
JAMA. 2019 Jun 25;321(24):2470-2471. doi: 10.1001/jama.2019.5149.
5
Electroencephalography-Guided Anesthetic Administration and Postoperative Delirium.脑电图引导下的麻醉给药与术后谵妄
JAMA. 2019 Jun 25;321(24):2469-2470. doi: 10.1001/jama.2019.5145.
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Electroencephalography-Guided Anesthetic Administration and Postoperative Delirium-Reply.脑电图引导下的麻醉给药与术后谵妄——回复
JAMA. 2019 Jun 25;321(24):2471-2472. doi: 10.1001/jama.2019.5161.
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Electroencephalography-Guided Anesthetic Administration and Postoperative Delirium.脑电图引导下的麻醉给药与术后谵妄
JAMA. 2019 Jun 25;321(24):2470. doi: 10.1001/jama.2019.5157.
8
Emergence delirium in children is related to epileptiform discharges during anaesthesia induction: An observational study.儿童麻醉诱导期出现谵妄与癫痫样放电有关：一项观察性研究。
Eur J Anaesthesiol. 2018 Dec;35(12):929-936. doi: 10.1097/EJA.0000000000000867.
9
Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction.在一项随机试验中监测麻醉深度可降低术后谵妄发生率，但不能降低术后认知功能障碍发生率。
Br J Anaesth. 2013 Jun;110 Suppl 1:i98-105. doi: 10.1093/bja/aet055. Epub 2013 Mar 28.
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Effects of two different anesthesia-analgesia methods on incidence of postoperative delirium in elderly patients undergoing major thoracic and abdominal surgery: study rationale and protocol for a multicenter randomized controlled trial.两种不同麻醉镇痛方法对老年胸腹部大手术患者术后谵妄发生率的影响：一项多中心随机对照试验的研究原理与方案
BMC Anesthesiol. 2015 Oct 13;15:144. doi: 10.1186/s12871-015-0118-5.

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Sedation management and processed EEG-based solutions during venovenous extracorporeal membrane oxygenation: a narrative review of key challenges and potential benefits.静脉-静脉体外膜肺氧合期间的镇静管理及基于脑电图处理的解决方案：关键挑战与潜在益处的叙述性综述
J Artif Organs. 2025 Mar 8. doi: 10.1007/s10047-025-01494-y.
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Characteristics of the top 100 cited electroencephalography articles on aging: a bibliometric analysis.关于衰老的被引用次数排名前100的脑电图文章的特征：一项文献计量分析。
Am J Transl Res. 2024 May 15;16(5):1749-1756. doi: 10.62347/CCTI1306. eCollection 2024.
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Modifiable risk factors for post-operative delirium in older adults undergoing major non-cardiac elective surgery: a multi-centre, trainee delivered observational cohort feasibility study and trainee survey.老年患者行非心脏大手术术后谵妄的可修正危险因素：一项多中心、住院医师执行的观察性队列可行性研究和住院医师调查。
BMC Geriatr. 2023 Jul 15;23(1):436. doi: 10.1186/s12877-023-04122-7.
4
Electroencephalogram Features of Perioperative Neurocognitive Disorders in Elderly Patients: A Narrative Review of the Clinical Literature.老年患者围手术期神经认知障碍的脑电图特征：临床文献的叙述性综述
Brain Sci. 2022 Aug 13;12(8):1073. doi: 10.3390/brainsci12081073.
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Raw and processed electroencephalography in modern anesthesia practice: a brief primer on select clinical applications.现代麻醉实践中的原始和处理后的脑电图：精选临床应用简介。
Korean J Anesthesiol. 2021 Dec;74(6):465-477. doi: 10.4097/kja.21349. Epub 2021 Aug 24.
6
Anesthesia and Cognitive Outcome in Elderly Patients: A Narrative Viewpoint.老年患者的麻醉与认知转归：一种叙述性观点。
J Neurosurg Anesthesiol. 2020 Jan;32(1):9-17. doi: 10.1097/ANA.0000000000000640.

本文引用的文献

1
Independent discussion sections for improving inferential reproducibility in published research.独立讨论部分可提高已发表研究的推理可重复性。
Br J Anaesth. 2019 Apr;122(4):413-420. doi: 10.1016/j.bja.2018.12.010. Epub 2019 Jan 22.
2
Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial.脑电图引导的麻醉管理对行大手术的老年患者术后谵妄的影响：ENGAGES 随机临床试验。
JAMA. 2019 Feb 5;321(5):473-483. doi: 10.1001/jama.2018.22005.
3
Reliability and accuracy of delirium assessments among investigators at multiple international centres.多个国际中心的研究人员进行谵妄评估的可靠性和准确性。
BMJ Open. 2018 Nov 21;8(11):e023137. doi: 10.1136/bmjopen-2018-023137.
4
Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit.术中在较低挥发性麻醉药物浓度下进行脑电图抑制可预测 ICU 中发生的术后谵妄。
Br J Anaesth. 2018 Jul;121(1):241-248. doi: 10.1016/j.bja.2017.10.024. Epub 2018 Jan 17.
5
An observational national study of anaesthetic workload and seniority across the working week and weekend in the UK in 2016: the 6th National Audit Project (NAP6) Activity Survey.2016 年英国一项关于麻醉工作量和资历的全国性观察性研究：第六次国家审计项目（NAP6）活动调查。
Br J Anaesth. 2018 Jul;121(1):134-145. doi: 10.1016/j.bja.2018.04.010. Epub 2018 May 21.
6
Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures in adults.用于改善成人非心脏及非神经外科手术后谵妄和认知功能障碍的处理后的脑电图和诱发电位技术。
Cochrane Database Syst Rev. 2018 May 15;5(5):CD011283. doi: 10.1002/14651858.CD011283.pub2.
7
Achieving Milestones as a Prerequisite for Proceeding With a Clinical Trial.达到里程碑是开展临床试验的前提。
Anesth Analg. 2018 Jun;126(6):1851-1858. doi: 10.1213/ANE.0000000000002680.
8
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial.术中使用氯胺酮预防老年患者大手术后的术后谵妄或疼痛：一项国际多中心双盲随机临床试验。
Lancet. 2017 Jul 15;390(10091):267-275. doi: 10.1016/S0140-6736(17)31467-8. Epub 2017 May 30.
9
Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram.与术中脑电图的视觉分析相比，爆发抑制比低估了脑电图抑制的绝对持续时间。
Br J Anaesth. 2017 May 1;118(5):755-761. doi: 10.1093/bja/aex054.
10
European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium.欧洲麻醉学会术后谵妄循证和共识指南。
Eur J Anaesthesiol. 2017 Apr;34(4):192-214. doi: 10.1097/EJA.0000000000000594.

Electroencephalography-guided anaesthetic administration does not impact postoperative delirium among older adults undergoing major surgery: an independent discussion of the ENGAGES trial.

作者信息

Ackland Gareth L, Pryor Kane O

机构信息

Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.

出版信息

Br J Anaesth. 2019 Aug;123(2):112-117. doi: 10.1016/j.bja.2019.03.016. Epub 2019 May 10.

DOI:10.1016/j.bja.2019.03.016
PMID:31079835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6676049/
Abstract
摘要