合理药物分析李斯特菌性脑膜炎与套细胞淋巴瘤相关。

Reasonable drug analysis of Listeria monocytogenes meningitis related to mantle cell lymphoma.

机构信息

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China; Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Tongzipo Road #138, Changsha 410013, China.

Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Tongzipo Road #138, Changsha 410013, China.

出版信息

J Infect Public Health. 2019 Sep-Oct;12(5):744-747. doi: 10.1016/j.jiph.2019.04.010. Epub 2019 May 10.

DOI:10.1016/j.jiph.2019.04.010

PMID:31080100

Abstract

We report a case of Listeria meningitis related to mantle cell lymphoma. A clinical pharmacist adjusted repeatedly the patient's anti-infective therapeutic regimen by analyzing the pharmacologic and pharmacokinetic characteristics of antibacterial drugs (such as cefotaxime, meropenem, etc.) due to the patient's repeated fever during hospitalization. To the best of our knowledge, this is the first case of Listeria meningitis related to mantle cell lymphoma treated successfully with meropenem reported in China. This case aims to optimize the anti-infection treatment regimen of Listeria meningitis and to provide a reference for clinicians and clinical pharmacists to use drugs rationally.

摘要

我们报告了一例与套细胞淋巴瘤相关的李斯特菌脑膜炎。由于患者在住院期间反复发热，临床药师通过分析抗菌药物（如头孢噻肟、美罗培南等）的药理和药代动力学特性，反复调整患者的抗感染治疗方案。据我们所知，这是中国首例成功用美罗培南治疗的与套细胞淋巴瘤相关的李斯特菌脑膜炎。本病例旨在优化李斯特菌脑膜炎的抗感染治疗方案，为临床医生和临床药师合理用药提供参考。