Weston V C, Punt J, Vloebeghs M, Watson A R, Ispahani P
Department of Microbiology, Queens Medical Centre, Nottingham, UK.
J Infect. 1998 Jul;37(1):77-8. doi: 10.1016/s0163-4453(98)90991-4.
Currently in many centres the extended spectrum cephalosporins (e.g. cefotaxime and ceftriaxone) are being used empirically for patients with suspected bacterial meningitis. We present a case of meningitis in a penicillin allergic paediatric renal transplant patient from whose cerebrospinal fluid (CSF) Listeria monocytogenes was cultured, despite four days of cefotaxime therapy. The patient was successfully treated with meropenem but required neuro-endoscopic intervention for hydrocephalus.
目前，在许多医疗中心，对于疑似细菌性脑膜炎的患者，经验性地使用广谱头孢菌素（如头孢噻肟和头孢曲松）进行治疗。我们报告了一例青霉素过敏的儿科肾移植患者发生脑膜炎的病例，尽管使用了四天的头孢噻肟治疗，但从其脑脊液（CSF）中培养出了单核细胞增生李斯特菌。该患者使用美罗培南成功治愈，但因脑积水需要进行神经内镜干预。
