Small M, Douglas J T, Lowe G D, MacCuish A C, Forbes C D
Haemostasis. 1986;16(6):417-23. doi: 10.1159/000215318.
Twenty type II (non-insulin-dependent) poorly controlled diabetics had tests of coagulation and platelet function performed while receiving high-dose sulphonylurea therapy and at 1 and 3 months following their conversion to insulin. Although no overall change in glycaemic control (assessed by glycosylated haemoglobin) was noted, a reduction in thrombin generation was observed, as judged by a significant fall in fibrinopeptide A concentrations. No changes in factor VIII coagulant activity (VIII:C), factor VIII-related antigen or antithrombin III were found. Glycosylated haemoglobin concentrations showed significant correlations with antithrombin III and factor VIII:C, suggesting that improved glycaemic control might lead to an improvement of antithrombin III function and lower factor VIII:C concentrations. No changes in platelet function were detected. The introduction of an insulin regimen that improves glycaemic control might lead to a reversal of the 'hypercoagulable state' found in type II diabetes.
20名II型（非胰岛素依赖型）血糖控制不佳的糖尿病患者在接受大剂量磺脲类药物治疗时以及转为胰岛素治疗后1个月和3个月时，进行了凝血和血小板功能测试。尽管未观察到血糖控制（通过糖化血红蛋白评估）的总体变化，但通过纤维蛋白肽A浓度的显著下降判断，凝血酶生成有所减少。未发现因子VIII促凝活性（VIII:C）、因子VIII相关抗原或抗凝血酶III有变化。糖化血红蛋白浓度与抗凝血酶III和因子VIII:C呈显著相关性，表明改善血糖控制可能导致抗凝血酶III功能改善以及因子VIII:C浓度降低。未检测到血小板功能有变化。引入能改善血糖控制的胰岛素治疗方案可能会逆转II型糖尿病中发现的“高凝状态”。
