Borsey D Q, Prowse C V, Gray R S, Dawes J, James K, Elton R A, Clarke B F
J Clin Pathol. 1984 Jun;37(6):659-64. doi: 10.1136/jcp.37.6.659.
Plasma beta-thromboglobulin, platelet factor 4, fibrinogen, fibrinopeptide A, antithrombin III, factor VIII related antigen, alpha 2-macroglobulin, platelet count, and total glycosylated haemoglobin were measured in three well matched groups of subjects: non-diabetic controls, diabetics without retinopathy, and diabetics with proliferative retinopathy. beta-thromboglobulin and platelet factor 4 concentrations were significantly higher in the diabetics with retinopathy than in the controls and platelet factor 4 was also increased in the diabetics without retinopathy compared with controls. Fibrinogen concentration was raised in diabetics without retinopathy compared with controls, diabetics with retinopathy compared with controls, and diabetics with retinopathy compared with those without. Fibrinopeptide A concentration did not differ significantly between groups. Antithrombin III levels were increased in diabetics with retinopathy compared with controls, and in diabetics with retinopathy compared with those without. Factor VIII related antigen values were higher in both the diabetic groups when compared with the controls. Fibrinopeptide A concentration correlated with both beta-thromboglobulin and platelet factor 4 in each of the three groups. Haemostatic abnormalities in diabetes have been shown, although a hypercoagulable state has not been confirmed. These changes in platelet and coagulation function may be secondary to the development of microvascular disease and their role in the pathogenesis of retinopathy remains uncertain.
对三组匹配良好的受试者进行了血浆β-血小板球蛋白、血小板第4因子、纤维蛋白原、纤维蛋白肽A、抗凝血酶III、因子VIII相关抗原、α2-巨球蛋白、血小板计数和糖化血红蛋白总量的检测：非糖尿病对照组、无视网膜病变的糖尿病患者和增殖性视网膜病变的糖尿病患者。有视网膜病变的糖尿病患者的β-血小板球蛋白和血小板第4因子浓度显著高于对照组，与对照组相比，无视网膜病变的糖尿病患者的血小板第4因子也有所升高。与对照组相比，无视网膜病变的糖尿病患者的纤维蛋白原浓度升高，与对照组相比，有视网膜病变的糖尿病患者的纤维蛋白原浓度升高，与无视网膜病变的糖尿病患者相比，有视网膜病变的糖尿病患者的纤维蛋白原浓度也升高。各组之间纤维蛋白肽A浓度无显著差异。与对照组相比，有视网膜病变的糖尿病患者的抗凝血酶III水平升高，与无视网膜病变的糖尿病患者相比，有视网膜病变的糖尿病患者的抗凝血酶III水平也升高。与对照组相比，两组糖尿病患者的因子VIII相关抗原值均较高。在三组中的每一组中，纤维蛋白肽A浓度均与β-血小板球蛋白和血小板第4因子相关。糖尿病患者存在止血异常，尽管高凝状态尚未得到证实。血小板和凝血功能的这些变化可能继发于微血管疾病的发展，它们在视网膜病变发病机制中的作用仍不确定。
