Iverson F, Newsome H, Hierlihy L
Food Chem Toxicol. 1987 Apr;25(4):305-7. doi: 10.1016/0278-6915(87)90127-x.
Polychlorinated diphenyl ethers are recognized environmental contaminants. Twelve of these compounds were tested for their ability to induce liver cytochrome P-450 and monooxygenase activities in Sprague-Dawley rats. All the compounds increased P-450 levels or increased monooxygenase activities in a manner resembling 3-methylcholanthrene, phenobarbital or a combination of both (mixed). The responses obtained resembled those of the polychlorinated biphenyls, some of which are known to be toxic.
