[Effect of lipid emulsions on nitrogen balance within the scope of perioperative parenteral feeding regimens].

Patients with colorectal cancer were parenterally fed before and after surgery by two different isocaloric regimens: One group was infused with high carbohydrate solutions (carbohydrate group), the other group with carbohydrate in combination with fat emulsions (fat group). The daily dose of fat was restricted to 1 g fat/kg BW/day. These conditions led to the following results: No significant changes in the protein balance were observed between the patients of the two regimens. The protein sparing effect and the synthesis of short living proteins were comparable. The infused fat emulsions were utilized without metabolic complications. Patients in the fat group were adequately supplied with essential fatty acids which was documented by the higher level of linolic acid in the blood. The biochemical and histological analysis of the liver samples which were excised on occasion of surgery gave comparable triglyceride content in both groups. In the fat group little lipid deposition was seen in the parenchymal cells but lipid droplets were observed in the reticuloendothelial system (v. Kupffer cells). Thus, distribution of fat droplets is different in the 2 groups. Unfortunately analysis of lipid depositions in the liver at the end of the parenteral nutrition could not be performed.