Howles C M, Macnamee M C, Edwards R G
Hum Reprod. 1987 Feb;2(2):91-4. doi: 10.1093/oxfordjournals.humrep.a136507.
Thirty-one patients superovulated with clomiphene citrate (CC) and human menopausal gonadotrophin (HMG) were given a single injection of 25 mg progesterone (P group) 6 h prior to injection of human chorionic gonadotrophin (HCG). Levels of urinary and plasma luteinizing hormone (LH) were significantly higher (P less than 0.001) immediately prior to HCG in the P group compared with thirty-one control patients who had HCG on the same night. Plasma levels of progesterone remained significantly elevated (P less than 0.02) for 80 h after injection in the P group, thereafter the level was similar to controls. The number of oocytes recovered, fertilized and replaced per patient was identical in both groups. However, four control patients had no embryos replaced due to failed fertilization. It is concluded that in the majority of P patients the timing of ovulation induction by HCG injection was appropriate as an LH surge was elicited thus reflecting a physiological stage of readiness, and elevated plasma progesterone levels around the time of oocyte recovery and in the early luteal phase do not increase the likelihood of the establishment of pregnancy in patients stimulated for in-vitro fertilization and embryo replacement (IVF/ER) with CC and HMG.
31名用枸橼酸氯米芬（CC）和人绝经期促性腺激素（HMG）进行超排卵的患者，在注射人绒毛膜促性腺激素（HCG）前6小时单次注射25mg孕酮（P组）。与31名在同一晚注射HCG的对照患者相比，P组在注射HCG前即刻尿和血浆促黄体生成素（LH）水平显著更高（P<0.001）。P组注射后80小时血浆孕酮水平仍显著升高（P<0.02），此后该水平与对照组相似。两组中每位患者回收、受精和移植的卵母细胞数量相同。然而，4名对照患者因受精失败未进行胚胎移植。结论是，在大多数P组患者中，注射HCG诱导排卵的时间是合适的，因为引发了LH峰，从而反映了生理上的准备阶段，并且在卵母细胞回收时和黄体早期血浆孕酮水平升高并不会增加接受CC和HMG刺激进行体外受精和胚胎移植（IVF/ER）患者妊娠成功的可能性。
