Howles C M, Macnamee M C, Edwards R G
Bourn Hall Clinic, Cambridge, UK.
Hum Reprod. 1988 May;3(4):409-12. doi: 10.1093/oxfordjournals.humrep.a136718.
Twenty-eight patients superovulated with clomiphene citrate (CC) and human menopausal gonadotrophin (HMG) were given a single injection of 25 mg progesterone (P group) 4 h prior to the ovulation-inducing injection of human chorionic gonadotrophin (HCG). Plasma and urinary LH levels were significantly higher (P less than 0.05) in the P group immediately prior to HCG compared to controls. Plasma progesterone concentrations were also elevated (P less than 0.01) in the P group from the time of injection to oocyte recovery. The number of mature oocytes recovered was also higher (P less than 0.001; 59% versus 40% in controls) and the time interval between oocyte recovery and insemination was also shorter (P less than 0.01) in the P group. The pregnancy rate/replacement 15 days after oocyte recovery was 39% versus 23% in the P and control groups respectively. It was concluded that as more mature oocytes were recovered in the P group, progesterone supplementation in the late follicular phase may be beneficial for patients undergoing GIFT. This was borne out when the first two GIFT patients pretreated in this way became pregnant.
28例用枸橼酸氯米芬（CC）和人绝经期促性腺激素（HMG）进行超排卵的患者，在注射人绒毛膜促性腺激素（HCG）诱导排卵前4小时单次注射25mg孕酮（P组）。与对照组相比，P组在注射HCG前即刻血浆和尿促黄体生成素（LH）水平显著更高（P<0.05）。从注射时到卵母细胞回收时，P组血浆孕酮浓度也升高（P<0.01）。P组回收的成熟卵母细胞数量也更多（P<0.001；对照组为40%，P组为59%），且P组卵母细胞回收与授精之间的时间间隔也更短（P<0.01）。卵母细胞回收后15天的妊娠率/移植率在P组和对照组分别为39%和23%。结论是，由于P组回收的成熟卵母细胞更多，卵泡晚期补充孕酮可能对接受配子输卵管内移植（GIFT）的患者有益。当最初两名以这种方式预处理的GIFT患者怀孕时，这一点得到了证实。
