Zhang Li, Xue Shuai, Yu JinYu, Si HeNan, Xu Ying, Li Jia, Ma FuZhe, Xu ZhongGao
The Department of Nephrology.
Department of Thyroid Surgery.
Medicine (Baltimore). 2019 May;98(19):e15433. doi: 10.1097/MD.0000000000015433.
Cases about IgAN associated with EP are rare and the pathogenesis is poorly understood. We reported a 74-year-old Chinese male who suffered the IgAN and EP at the same time and explored a possible pathophysiologic link and points toward the possible pathogenesis.
The patient complained deteriorating symptoms (erythrodermia, skin pruritus, and pain) of psoriasis and obvious pitting edema on his legs.
The patient was diagnosed as IgAN and EP concurrently according to medical history, physical examination, laboratory test, and pathology.
Intravenous dexamethasone (5 mg/day) and oral ciclosporin (200 mg twice a day).
The patient's symptoms of psoriasis and IgA nephropathy improved obviously after 11-day treatment and discharged from the hospital.
IgAN should be considered when the patient is diagnosed as EP. The combination of dexamethasone and ciclosporin may be effective option for patients with IgAN and EP concurrently.
IgA肾病（IgAN）合并脓疱型银屑病（EP）的病例罕见，发病机制尚不清楚。我们报告了一名74岁的中国男性，他同时患有IgAN和EP，并探讨了可能的病理生理联系及潜在发病机制。
患者抱怨银屑病症状（红皮病、皮肤瘙痒和疼痛）恶化，腿部出现明显的凹陷性水肿。
根据病史、体格检查、实验室检查和病理结果，患者被诊断为同时患有IgAN和EP。
静脉注射地塞米松（5毫克/天）和口服环孢素（200毫克，每日两次）。
经过11天的治疗，患者的银屑病和IgA肾病症状明显改善并出院。
当患者被诊断为EP时，应考虑IgAN。地塞米松和环孢素联合使用可能是同时患有IgAN和EP患者的有效选择。
