VA Sacramento Medical Center, Department of Veterans Affairs, Northern California Health Care System, Mather, CA, United States of America.
Department of Dermatology, School of Medicine, University of California, Davis, CA, United States of America.
Autoimmun Rev. 2014 Apr-May;13(4-5):490-5. doi: 10.1016/j.autrev.2014.01.008. Epub 2014 Jan 13.
Psoriasis is a chronic inflammatory multi organ disease with well characterized pathology occurring in the skin and often the joints. Although the disease has many characteristic and even pathognomonic features, no established diagnostic criteria exist for cutaneous psoriasis and there is no unified classification for the clinical spectrum of the disease. Prior approaches that have been taken to classify psoriasis include age of onset, severity of the disease, and morphologic evaluation. The latter has yielded plaque, guttate, pustular, and erythrodermic as subtypes of psoriasis. Unlike other autoimmune diseases, histopathological examination and blood tests are generally not valuable tools in making the diagnosis of psoriasis. However, on occasion, dermatopathologic evaluation may be helpful in confirming the diagnosis of psoriasis. Thus, in most cases the diagnosis of psoriasis is dependent primarily on pattern recognition that is morphologic evaluation of skin lesions and joints.
银屑病是一种慢性炎症性多器官疾病,其特征为皮肤和关节的病理表现。虽然该疾病具有许多特征性甚至是特异性的表现,但目前还没有用于诊断银屑病的既定标准,也没有针对该疾病临床谱的统一分类。以前用于分类银屑病的方法包括发病年龄、疾病严重程度和形态学评估。后者将斑块型、点滴状、脓疱型和红皮病型作为银屑病的亚型。与其他自身免疫性疾病不同,组织病理学检查和血液检查通常不是诊断银屑病的有价值工具。然而,有时皮肤病理评估可能有助于确认银屑病的诊断。因此,在大多数情况下,银屑病的诊断主要依赖于对皮肤病变和关节的形态学评估的模式识别。