Narloch Jerzy, Glinkowski Wojciech M
Chair and Department of Orthopaedics and Traumatology of the Locomotor System, Medical University of Warsaw, 02-005 Warsaw, Poland.
Polish Telemedicine and eHealth Society, 03-728 Warsaw, Poland.
J Clin Med. 2019 May 12;8(5):669. doi: 10.3390/jcm8050669.
We aimed to compare proximal femur geometry and biomechanics in postmenopausal women with osteoarthritis (OA) and/or osteoporosis (OP), using quantitative computed tomography (QCT). A retrospective analysis of QCT scans of the proximal femur of 175 postmenopausal women was performed. Morphometric and densitometric data of the proximal femur were used to evaluate its biomechanics. We found, 21 had a normal bone mineral density (BMD), 72 had osteopenia, and 81 were diagnosed with OP. Radiographic findings of hip OA were seen in 43.8%, 52.8%, and 39.5% of the normal BMD, osteopenic, and OP groups, respectively ( < 0.05). OA was significantly correlated with total hip volume (r = 0.21), intertrochanteric cortical volume (r = 0.25), and trochanteric trabecular volume (r = 0.20). In each densitometric group, significant differences in hip geometry and BMD were found between the OA and non-OA subgroups. Hip OA and OP often coexist. In postmenopausal women, these diseases coexist in 40% of cases. Both OA and OP affect hip geometry and biomechanics. OA does so regardless of densitometric status. Changes are mostly reflected in the cortical bone. OA leads to significant changes in buckling ratio (BR) in both OP and non-OP women.
我们旨在使用定量计算机断层扫描（QCT）比较患有骨关节炎（OA）和/或骨质疏松症（OP）的绝经后女性的股骨近端几何结构和生物力学。对175名绝经后女性的股骨近端QCT扫描进行了回顾性分析。使用股骨近端的形态学和密度测定数据来评估其生物力学。我们发现，21人骨矿物质密度（BMD）正常，72人骨质减少，81人被诊断为OP。在正常BMD组、骨质减少组和OP组中，髋部OA的影像学表现分别见于43.8%、52.8%和39.5%（<0.05）。OA与全髋关节体积（r = 0.21）、转子间皮质体积（r = 0.25）和转子小梁体积（r = 0.20）显著相关。在每个密度测定组中，OA和非OA亚组之间在髋部几何结构和BMD方面存在显著差异。髋部OA和OP常共存。在绝经后女性中，这些疾病在40%的病例中共存。OA和OP均会影响髋部几何结构和生物力学。无论密度测定状态如何，OA都会产生影响。变化主要反映在皮质骨中。OA会导致OP和非OP女性的屈曲比（BR）发生显著变化。
