Lichter W, Wellham L L, Sigel M M, Ghaffar A
J Immunol. 1979 Jan;122(1):8-11.
Extracts of a marine tunicate, Ecteinascidia turbinata (Ete) were previously shown to be capable of suppressing humoral and cellular immune responses in vivo and in vitro. In the present work we have examined the mechanisms of suppression in Ete-treated DBA/2 and BALB/c mice. Treatment with Ete resulted in a significant splenomegaly accompanied by a diminished response to mitogenic stimulation, reaching coincident maxima of effect at days 4 to 6. Spleen size and blastogenic reaction returned to normal at 12 to 21 days. Cells from enlarged spleens inhibited blastogenic responses of normal splenocytes to Con A. Marker studies indicated that the suppressor activity was exerted by cells possessing T lymphocyte characteristics.
先前的研究表明，海洋被囊动物海鞘（Ecteinascidia turbinata，简称Ete）的提取物能够在体内和体外抑制体液免疫和细胞免疫反应。在本研究中，我们探讨了Ete处理的DBA/2和BALB/c小鼠的免疫抑制机制。用Ete处理后，小鼠脾脏显著肿大，同时对有丝分裂原刺激的反应减弱，在第4至6天达到最大效应。脾脏大小和增殖反应在12至21天恢复正常。来自肿大脾脏的细胞抑制正常脾细胞对刀豆蛋白A的增殖反应。标记研究表明，抑制活性是由具有T淋巴细胞特征的细胞发挥的。
