用抗淋巴细胞血清处理的豚鼠血液淋巴细胞的抑制活性

Suppressor activity of blood lymphocytes from guinea-pigs treated with ALS.

作者信息

Rudnicka W

出版信息

Immunology. 1980 Mar;39(3):435-40.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457794/

Abstract

PHA-induced transformation of guinea-pig lymphocytes was profoundly inhibited by the injection of antilymphocyte serum (ALS). This effect, seen 24 h after ALS administration, disappeared within 3 days. Lymphocytes of animals injected with ALS 24 h earlier inhibited the blast transformation of autologous normal lymphocytes. The supernatants of short term cultures of such cells, even after pre-treatment with puromycin, exhibited the same inhibitory activity. It is suggested that the immunosuppressive effect of ALS is not limited to its direct action on lymphocytes.

摘要

注射抗淋巴细胞血清（ALS）可显著抑制PHA诱导的豚鼠淋巴细胞转化。这种效应在给予ALS后24小时出现，3天内消失。提前24小时注射ALS的动物的淋巴细胞抑制了自体正常淋巴细胞的母细胞转化。即使在用嘌呤霉素预处理后，这些细胞短期培养的上清液仍表现出相同的抑制活性。提示ALS的免疫抑制作用不限于其对淋巴细胞的直接作用。

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本文引用的文献

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Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.淋巴细胞活化。I. T淋巴细胞和B淋巴细胞对植物有丝分裂原的反应。

Clin Exp Immunol. 1971 Oct;9(4):483-98.

2

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Prolongation of allograft survival in mice by administration of anti-Thy 1 serum. I. Mediation by in vivo activation of regulatory T cells.通过给予抗Thy 1血清延长小鼠同种异体移植物存活时间。I. 体内调节性T细胞激活的介导作用

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Suppressor activity of splenocytes from mice treated with Ecteinascidia turbinata extract.被海鞘提取物处理过的小鼠脾细胞的抑制活性。

J Immunol. 1979 Jan;122(1):8-11.

6

Role of adherent cells in immune responses to phytohemagglutinin and concanavalin A.黏附细胞在对植物血凝素和伴刀豆球蛋白A免疫反应中的作用。

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