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用抗淋巴细胞血清处理的豚鼠血液淋巴细胞的抑制活性

Suppressor activity of blood lymphocytes from guinea-pigs treated with ALS.

作者信息

Rudnicka W

出版信息

Immunology. 1980 Mar;39(3):435-40.

PMID:6449472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457794/
Abstract

PHA-induced transformation of guinea-pig lymphocytes was profoundly inhibited by the injection of antilymphocyte serum (ALS). This effect, seen 24 h after ALS administration, disappeared within 3 days. Lymphocytes of animals injected with ALS 24 h earlier inhibited the blast transformation of autologous normal lymphocytes. The supernatants of short term cultures of such cells, even after pre-treatment with puromycin, exhibited the same inhibitory activity. It is suggested that the immunosuppressive effect of ALS is not limited to its direct action on lymphocytes.

摘要

注射抗淋巴细胞血清（ALS）可显著抑制PHA诱导的豚鼠淋巴细胞转化。这种效应在给予ALS后24小时出现，3天内消失。提前24小时注射ALS的动物的淋巴细胞抑制了自体正常淋巴细胞的母细胞转化。即使在用嘌呤霉素预处理后，这些细胞短期培养的上清液仍表现出相同的抑制活性。提示ALS的免疫抑制作用不限于其对淋巴细胞的直接作用。

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本文引用的文献

1
Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.淋巴细胞活化。I. T淋巴细胞和B淋巴细胞对植物有丝分裂原的反应。
Clin Exp Immunol. 1971 Oct;9(4):483-98.
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The effect of heterologous anti-lymphocytic serum on the small lymphocyte population of rats.异种抗淋巴细胞血清对大鼠小淋巴细胞群体的影响。
J Exp Med. 1968 Jul 1;128(1):111-9. doi: 10.1084/jem.128.1.111.
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Characterisation and separation of mouse lymphocyte subpopulations responding to phytohemagglutinin and pokeweed mitogens.对响应植物血凝素和商陆有丝分裂原的小鼠淋巴细胞亚群的表征与分离。
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Prolongation of allograft survival in mice by administration of anti-Thy 1 serum. I. Mediation by in vivo activation of regulatory T cells.通过给予抗Thy 1血清延长小鼠同种异体移植物存活时间。I. 体内调节性T细胞激活的介导作用
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Suppressor activity of splenocytes from mice treated with Ecteinascidia turbinata extract.被海鞘提取物处理过的小鼠脾细胞的抑制活性。
J Immunol. 1979 Jan;122(1):8-11.
6
Role of adherent cells in immune responses to phytohemagglutinin and concanavalin A.黏附细胞在对植物血凝素和伴刀豆球蛋白A免疫反应中的作用。
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