Sollid L M, Kvale D, Brandtzaeg P, Markussen G, Thorsby E
J Immunol. 1987 Jun 15;138(12):4303-6.
Recombinant interferon-gamma (IFN-gamma) increased in a dose-dependent manner the intracellular pool, the membrane expression, and the shedding of secretory component (SC) in human colonic adenocarcinoma cell line (HT-29). A similar dose-response relationship was observed when we examined the binding of polymeric IgA to HT-29 cells treated with IFN-gamma, thus reflecting expression of functional SC. Because IFN-gamma is produced by T cells during immune responses, activated T cells may be able to promote the external transport of dimeric IgA and pentameric IgM and thereby enhance the efferent limb of the secretory immune system. This is, therefore, the first observation indicating how the secretory transport capacity may be adjusted to increased local immunoglobulin production.
重组干扰素-γ（IFN-γ）以剂量依赖的方式增加了人结肠腺癌细胞系（HT-29）中分泌成分（SC）的细胞内池、膜表达及脱落。当我们检测聚合型IgA与经IFN-γ处理的HT-29细胞的结合时，观察到了类似的剂量反应关系，从而反映了功能性SC的表达。由于IFN-γ是T细胞在免疫反应过程中产生的，活化的T细胞可能能够促进二聚体IgA和五聚体IgM的外向转运，从而增强分泌免疫系统的传出支。因此，这是首次观察到分泌转运能力如何根据局部免疫球蛋白产生的增加进行调节。
