Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia.
Agriculture Biotechnology Research Institute of Iran (ABRII), East and North-East Branch, P.O. Box 91735 844, Mashhad, Iran.
Biomed Res Int. 2017;2017:2576921. doi: 10.1155/2017/2576921. Epub 2017 Nov 19.
To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats.
为了研究 PKC 提取物（OligoPKC）的益生元和免疫调节作用，将 24 只雄性大鼠随机分为三组，分别给予基础日粮（对照组）、基础日粮中添加 0.5% OligoPKC 和基础日粮中添加 1% OligoPKC，喂养 4 周。结果发现，OligoPKC 对生长参数没有显著影响。然而，它增加了总有益菌和有益菌的数量，同时减少了病原体的数量。OligoPKC 增加了血清和盲肠内容物中免疫球蛋白的浓度。它还增强了肝脏的抗氧化能力，同时减少了肝组织中的脂质过氧化。OligoPKC 影响了肠道中与免疫系统功能相关基因的表达。因此，OligoPKC 可以被认为是一种潜在的基于甘露聚糖的益生元，因为它对模型大鼠的健康和幸福有有益的影响。
