Department of Legal Medicine, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.
Environ Health Prev Med. 2019 May 13;24(1):31. doi: 10.1186/s12199-019-0792-x.
In Japan, because the most common site of drowning among patients with epilepsy is the bathtub, showering is generally recommended as an alternative to bathing. We herein report a case involving a female patient with epilepsy who drowned while showering. She had been diagnosed with epilepsy approximately 25 years previously, and her condition had progressed to refractory epilepsy. Carbamazepine, levetiracetam, lamotrigine, clobazam, and perampanel were prescribed daily. One day while showering, the patient was found lying with her face immersed in water that had accumulated on the floor of the bathtub. A forensic autopsy revealed water in the stomach, trachea, and proximal regions of both lung bronchi as well as white and red foam on the pharynx and larynx. A total of 1.9 μg/mL of lamotrigine, 0.14 μg/mL of carbamazepine, and 0.069 μg/mL of perampanel were detected in the patient's blood. The patient's cause of death was determined to be drowning due to an epileptic seizure. Although the patient was prescribed five types of antiepileptic medication, only three were detected in her blood. The current case demonstrates that drowning can occur while showering, suggesting that it is unsafe for patients with medication nonadherence. To prevent unintentional deaths in the bathroom, we recommend that patients with epilepsy maintain high adherence to all prescriptions and are supervised by a family member, even when showering. The current case is the first autopsy report of a patient with epilepsy who drowned while showering.
在日本,由于癫痫患者溺水最常见的地点是浴缸,因此一般建议淋浴替代泡澡。在此,我们报告了一例癫痫患者在淋浴时溺水的病例。该患者约 25 年前被诊断为癫痫,病情进展为难治性癫痫。她每天服用卡马西平、左乙拉西坦、拉莫三嗪、氯巴占和培米替尼。有一天,她在洗澡时被发现脸浸在浴缸地板上积水中。法医解剖发现胃、气管和双肺支气管近端有水,咽部和喉部有白色和红色泡沫。在患者血液中检测到 1.9μg/mL 的拉莫三嗪、0.14μg/mL 的卡马西平、0.069μg/mL 的培米替尼。患者的死亡原因被确定为癫痫发作导致溺水。尽管该患者服用了五种抗癫痫药物,但仅在其血液中检测到三种。本病例表明,即使患者遵医嘱服药,癫痫发作时仍可能在淋浴时溺水,提示药物不依从的患者存在安全隐患。为了防止浴室中发生意外死亡,我们建议所有癫痫患者保持高度遵医嘱服药,并在洗澡时由家人监督。本病例是首例癫痫患者淋浴溺水的尸检报告。