Suita S, Ikeda K, Doki T, Naito K, Handa N, Matsuo S, Ohgami H
J Pediatr Surg. 1987 May;22(5):401-5. doi: 10.1016/s0022-3468(87)80257-9.
Zinc status was studied in 36 children with biliary atresia and in ten children with Hirschsprung's disease or anorectal anomalies. Changes in preoperative and postoperative plasma and urinary zinc levels were measured in 16 children with biliary atresia and ten children with Hirschsprung's disease or anorectal anomalies. Hypozincemia was evident in children with biliary atresia preoperatively and became severe with time when adequate zinc supplementation was not given. Follow-up studies were done in 20 children with biliary atresia aged between 9 months to 10 years. The children with poor bile excretion and impaired liver function tended to have hypozincemia and a high excretion of zinc. Growth retardation was also common in these children. Careful monitoring and appropriate supplementation of micronutrients, including zinc is probably important for normal growth in children with biliary atresia.
对36例胆道闭锁患儿和10例先天性巨结肠或肛门直肠畸形患儿的锌状态进行了研究。对16例胆道闭锁患儿和10例先天性巨结肠或肛门直肠畸形患儿术前和术后的血浆及尿锌水平变化进行了测量。胆道闭锁患儿术前明显存在低锌血症，若未给予充足的锌补充，随着时间推移会变得严重。对20例年龄在9个月至10岁之间的胆道闭锁患儿进行了随访研究。胆汁排泄不良和肝功能受损的患儿往往存在低锌血症且锌排泄量高。这些患儿生长发育迟缓也很常见。对包括锌在内的微量营养素进行仔细监测并适当补充，可能对胆道闭锁患儿的正常生长很重要。
