Hambidge K M, Krebs N F, Lilly J R, Zerbe G O
Department of Pediatrics, University of Colorado Health Sciences Center, Denver.
J Pediatr Gastroenterol Nutr. 1987 Nov-Dec;6(6):872-7. doi: 10.1097/00005176-198711000-00009.
The objective of this study was to undertake a pilot assessment of zinc status in infants and children with extrahepatic biliary atresia. Plasma zinc concentrations and urine zinc excretion rates were measured longitudinally in 45 infants and young children with this disorder. The mean (+/- SD) plasma zinc (298 observations) was 56.8 +/- 17.9 micrograms/dl (controls 85.6 +/- 10.8). Plasma zinc was not correlated with age and did not appear to be related to repeated surgical procedures or to episodes of cholangitis. Plasma zinc was only weakly correlated with serum albumin (r = 0.27, p less than 0.001). The 24-h urine zinc excretion rates were correlated with age but not so strongly as for normal children. Hyperzincuria was evident from the linear regression equation of 24-h urine zinc on age. On a body weight basis, urine zinc excretion rates were approximately 6 times normal for the first 2 years and remained high across the entire age range. To replace these losses, net zinc absorption would need to increase by 40%. The relationship of these data to the zinc nutritional status of these patients and to their underlying hepatic disease remains to be clarified by more definitive studies.
本研究的目的是对肝外胆道闭锁患儿的锌状态进行初步评估。对45例患有该疾病的婴幼儿的血浆锌浓度和尿锌排泄率进行了纵向测量。血浆锌的均值（±标准差）（298次观察）为56.8±17.9微克/分升（对照组为85.6±10.8）。血浆锌与年龄无关，似乎也与重复的外科手术或胆管炎发作无关。血浆锌仅与血清白蛋白呈弱相关（r = 0.27，p < 0.001）。24小时尿锌排泄率与年龄相关，但不如正常儿童那样密切。从24小时尿锌与年龄的线性回归方程可以明显看出高锌尿症。以体重为基础，头两年尿锌排泄率约为正常的6倍，并且在整个年龄范围内都保持较高水平。为了弥补这些损失，锌的净吸收需要增加40%。这些数据与这些患者的锌营养状况及其潜在肝病之间的关系仍有待更确切的研究来阐明。
