Pollack S B, Emmons S I
J Immunol. 1979 Feb;122(2):718-22.
Human antibody-dependent cellular cytotoxicity (ADCC) mediated by K cells is shown in this study to be inhibited by autologous lymphocytes. Inhibitor activity resides in a population of lymphocytes lacking Fc receptors, i.e., depletion of Fc receptor-bearing lymphocytes on immobolized enriches for inhibition. A T cell-enriched population does not inhibit. The effect is not steric inhibition since addition of large numbers of sheep or chicken erythrocytes does not decrease ADCC. Spontaneous cytotoxicity mediated by NK cells in the absence of added antibody is not inhibited by the FcR-depleted population, indicating that K and NK cells differ from each other in this respect.
本研究表明，由K细胞介导的人类抗体依赖性细胞毒性（ADCC）受到自体淋巴细胞的抑制。抑制活性存在于缺乏Fc受体的淋巴细胞群体中，即固定化富集后去除携带Fc受体的淋巴细胞可增强抑制作用。富含T细胞的群体不具有抑制作用。这种效应并非空间位阻抑制，因为添加大量绵羊或鸡红细胞并不会降低ADCC。在没有添加抗体的情况下，由NK细胞介导的自发细胞毒性不受FcR缺失群体的抑制，这表明K细胞和NK细胞在这方面存在差异。
