人T淋巴细胞亚群介导的抗体依赖性细胞毒性：对人红细胞和自体淋巴细胞的杀伤作用

Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: killing of human erythrocytes and autologous lymphoid cells.

作者信息

Katz P, Fauci A S

出版信息

Immunology. 1980 Mar;39(3):407-16.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457808/

Abstract

The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (TM) displayed no ADCC activity TG-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.

摘要

本研究在抗体依赖性细胞毒性（ADCC）试验中，对人T淋巴细胞亚群针对人红细胞（HRBC）和自体淋巴细胞的细胞毒性能力进行了表征。带有免疫球蛋白IgG的Fc受体的T细胞（TG）能够裂解包被抗体的HRBC和自体淋巴细胞，而带有IgM表面Fc受体的T细胞（TM）则无ADCC活性。用聚集Ig处理后，通过阻断表面Fc受体可抑制TG细胞介导的ADCC。裸细胞和低亲和力E花环形成细胞对这些靶标也具有类似的ADCC活性。

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本文引用的文献

1

Studies of the human lymphocyte receptor for heat-aggregated or antigen-complexed immunoglobulin.人类淋巴细胞对热聚集或抗原复合免疫球蛋白受体的研究。

J Exp Med. 1974 Aug 1;140(2):508-22. doi: 10.1084/jem.140.2.508.

2

Haemolytic activity of human blood monocytes. Lysis of human erythrocytes treated with anti-A serum.人血单核细胞的溶血活性。用抗A血清处理的人红细胞的裂解。

Clin Exp Immunol. 1973 Jan;13(1):29-43.

3

Temporary inhibition of antibody-dependent, cell-mediated cytotoxicity by pretreatment of human attacking cells with ammonium chloride.通过用氯化铵预处理人类攻击细胞来暂时抑制抗体依赖性细胞介导的细胞毒性。

J Immunol. 1976 Apr;116(4):1170-2.

4

Expression of a receptor for IgM by human T cells in vitro.人T细胞在体外表达IgM受体。

Eur J Immunol. 1975 Aug;5(8):565-9. doi: 10.1002/eji.1830050812.

5

Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells.人淋巴细胞上与绵羊红细胞形成自发玫瑰花结的IgG分子受体。

Eur J Immunol. 1975 Jan;5(1):70-2. doi: 10.1002/eji.1830050115.

6

Human bone marrow lymphocytes. Cytotoxic effector cells in the bone marrow of normal individuals.人骨髓淋巴细胞。正常个体骨髓中的细胞毒性效应细胞。

J Clin Invest. 1976 Apr;57(4):826-35. doi: 10.1172/JCI108358.

7

Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen.人B淋巴细胞的激活。II. 人扁桃体和外周血B淋巴细胞对商陆有丝分裂原多克隆激活的PFC反应中的细胞相互作用。

J Immunol. 1976 Dec;117(6):2100-4.

8

Activation of human B lymphocytes. I. Direct plaque-forming cell assay for the measurement of polyclonal activation and antigenic stimulation of human B lymphocytes.人类B淋巴细胞的激活。I. 用于测量人类B淋巴细胞多克隆激活和抗原刺激的直接空斑形成细胞测定法。

J Exp Med. 1976 Sep 1;144(3):674-84. doi: 10.1084/jem.144.3.674.

9

Spontaneous cell-mediated cytotoxicity in humans. Distribution and characterization of the effector cell.人类自发细胞介导的细胞毒性。效应细胞的分布与特征

Clin Exp Immunol. 1978 Aug;33(2):309-18.

10

Human lymphocyte, monocyte, and neutrophil antibody-dependent cell-mediated cytotoxicity toward human erythrocytes.人淋巴细胞、单核细胞和中性粒细胞对人红细胞的抗体依赖性细胞介导的细胞毒性。

Cell Immunol. 1978 Nov;41(1):122-33. doi: 10.1016/s0008-8749(78)80032-x.

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