Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA.
Cancer Cell. 2019 May 13;35(5):709-711. doi: 10.1016/j.ccell.2019.04.008.
In this issue of Cancer Cell, Elgendy et al. describe the use of intermittent fasting as a strategy to reduce tumor glucose levels and sensitize otherwise resistant tumor cells to metformin. The authors demonstrate that intermittent fasting before metformin treatment sensitized tumors to metformin and significantly reduced tumor growth.
在本期《癌细胞》杂志中，Elgendy 等人描述了间歇性禁食作为一种降低肿瘤葡萄糖水平的策略，并使原本对二甲双胍有抗性的肿瘤细胞对其敏感。作者表明，在二甲双胍治疗前进行间歇性禁食会使肿瘤对二甲双胍敏感，并显著减少肿瘤生长。
