Chuks Ejezie G, Okeke G C
J Trop Med Hyg. 1987 Jun;90(3):149-51.
Praziquantel (Biltricide, Bayer AG), which has been found to be very effective in the treatment of schistosomiasis, was evaluated to formulate the minimal cost-effective dose in selective chemotherapy of 135 school children aged 6-15 years. Side effects were minimal. The drug had no effect on the heavy load of intestinal helminths found in 78.1% of the subjects. However, it cleared the urinary schistosomiasis in all but 0.9% of the subjects at the dosages used and after 18 months only 0.59% of the entire school population had new infections. The targetted chemotherapy reduced the prevalence rate from 16.0% to 0.59%. The lowest dose of 1 X 20 mg/kg body weight was able to clear the light infections of 52 subjects. This has a great economic advantage because the drug is expensive and most of the infections in Nigeria are light to moderate.
吡喹酮（商品名：必特螺旋，拜耳公司）已被证实对治疗血吸虫病非常有效，本研究对其进行评估，以确定针对135名6至15岁学童进行选择性化疗时的最低成本效益剂量。副作用极小。该药物对78.1%的受试者体内大量的肠道蠕虫没有效果。然而，在所使用的剂量下，除了0.9%的受试者外，它清除了所有受试者的泌尿血吸虫病，并且在18个月后，整个学校人群中只有0.59%有新感染。靶向化疗使患病率从16.0%降至0.59%。最低剂量1×20mg/kg体重能够清除52名受试者的轻度感染。这具有很大的经济优势，因为该药物价格昂贵，而尼日利亚的大多数感染为轻度至中度。
