在贝赫拉省学童中开展选择性群体化疗：联合国儿童基金会/阿拉伯埃及共和国/世界卫生组织血吸虫病控制项目
Selective population chemotherapy among schoolchildren in Beheira governorate: the UNICEF/Arab Republic of Egypt/WHO Schistosomiasis Control Project.
作者信息
el Malatawy A, el Habashy A, Lechine N, Dixon H, Davis A, Mott K E
机构信息
UNICEF, Cairo, Egypt.
出版信息
Bull World Health Organ. 1992;70(1):47-56.
Selective population chemotherapy using a single dose of praziquantel (40 mg per kg body weight), which was offered to 29,365 schoolchildren in Abu El Matameer and 40,241 in Abo Homos districts, Beheira governorate in the Nile delta, reduced the prevalence of schistosomiasis from 75.4% to 40.9% (reduction of 45.8%) and from 80.5% to 30.8% (reduction of 61.7%), respectively. Of those with only S. mansoni infection, 10.6% before treatment and 1.7% one year later had more than 800 eggs per gram of faeces. The prevalence of S. haematobium in Abu El Matameer was reduced from 35.4% to 7.4% after a single treatment. Infections with both S. mansoni and S. haematobium were reduced by more than 90% after one year. These reductions in prevalence and intensity of schistosomiasis in the face of continuing transmission and water contact augur well for the future role of chemotherapy in control programmes.
在尼罗河三角洲的贝赫拉省，对阿布·埃尔·马塔米尔的29365名学童和阿布·霍莫斯地区的40241名学童使用单剂量吡喹酮（每公斤体重40毫克）进行选择性群体化疗，分别将血吸虫病患病率从75.4%降至40.9%（降低了45.8%），以及从80.5%降至30.8%（降低了61.7%）。在仅感染曼氏血吸虫的人群中，治疗前每克粪便中有超过800个虫卵的比例为10.6%，一年后降至1.7%。在阿布·埃尔·马塔米尔，单次治疗后埃及血吸虫的患病率从35.4%降至7.4%。一年后，同时感染曼氏血吸虫和埃及血吸虫的情况减少了90%以上。尽管存在持续传播和接触水源的情况，但血吸虫病患病率和感染强度的这些降低对于化疗在控制项目中的未来作用而言是个好兆头。
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