Tumor Stroma Interactions, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxenbourg, Luxembourg.
Cells. 2019 May 13;8(5):449. doi: 10.3390/cells8050449.
Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their dual role in promoting and inhibiting cancer progression depending on their phenotype. To continue, we describe the influence of different tumor microenvironment factors such as hypoxia on B cells functions and differentiation. Finally, the role of B cells in response to therapy and as potential target is examined. In accordance with the importance of B cells in immuno-oncology, we conclude that more studies are required to throw light on the precise role of B cells in the tumor microenvironment in order to have a better understanding of their functions, and to design new strategies that efficiently target these cells by immunotherapy.
肿瘤浸润淋巴细胞被认为是控制肿瘤进展的关键。虽然 T 淋巴细胞的作用已经得到了广泛的研究，但 B 细胞在这方面的功能仍不明确。在这篇综述中，我们拟探讨 B 细胞在肿瘤免疫中的作用。首先，根据其表型，我们定义了它们在促进和抑制癌症进展中的双重作用。其次，我们描述了不同的肿瘤微环境因素，如缺氧对 B 细胞功能和分化的影响。最后，研究了 B 细胞在治疗反应中的作用以及作为潜在靶点的作用。鉴于 B 细胞在免疫肿瘤学中的重要性，我们得出结论，需要进一步研究来阐明 B 细胞在肿瘤微环境中的精确作用，以便更好地了解其功能，并设计通过免疫疗法有效靶向这些细胞的新策略。
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