肿瘤浸润 B 细胞：在肺癌抗肿瘤免疫中的作用及应用。
Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer.
机构信息
Department of Translational Medicine, The First Hospital of Jilin University, Changchun, 130061, China.
Department of Thoracic surgery, The First Hospital of Jilin University, Changchun, 130021, China.
出版信息
Cell Mol Immunol. 2019 Jan;16(1):6-18. doi: 10.1038/s41423-018-0027-x. Epub 2018 Apr 8.
Abstract
Evidence indicates that lung cancer development is a complex process that involves interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating immune cells play a significant role in the promotion or inhibition of tumor growth. As an integral component of the tumor microenvironment, tumor-infiltrating B lymphocytes (TIBs) exist in all stages of cancer and play important roles in shaping tumor development. Here, we review recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment.
摘要
有证据表明，肺癌的发生发展是一个复杂的过程，涉及肿瘤细胞、基质成纤维细胞和免疫细胞之间的相互作用。肿瘤浸润免疫细胞在促进或抑制肿瘤生长方面发挥着重要作用。作为肿瘤微环境的一个组成部分，肿瘤浸润 B 淋巴细胞（TIBs）存在于癌症的所有阶段，并在塑造肿瘤发展方面发挥着重要作用。在这里，我们回顾了最近的临床前和临床研究，这些研究概述了 TIBs 在肺癌发生发展中的作用，评估了它们的预后意义，并探讨了基于 B 细胞的免疫疗法治疗肺癌的潜在益处。
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