5',5'''-p1,p4-四磷酸二腺苷类似物对组蛋白H1的ADP-核糖基化作用的抑制
Inhibition of ADP-ribosylation of histone H1 by analogs of diadenosine 5',5'''-p1,p4-tetraphosphate.
作者信息
Suzuki H, Tanaka Y, Buonamassa D T, Farina B, Leone E
出版信息
Mol Cell Biochem. 1987 Mar;74(1):17-20. doi: 10.1007/BF00221908.
PMID:3108656
Abstract
The effects of analogs of diadenosine 5',5'''-p1,p4-tetraphosphate (Ap4A) were examined on the ADP-ribosylation reaction of histone H1 catalysed by purified bovine thymus poly(ADP-ribose)transferase. Among the compounds tested, epsilon Ap4A and ApCH2pppA were shown to be the most efficient inhibitors of the enzyme. From kinetic studies of their action, it appears that epsilon Ap4A and ApCH2pppA might be 'mixed type' inhibitors.
摘要
研究了5',5'''-p1,p4-四磷酸二腺苷（Ap4A）类似物对纯化的牛胸腺聚（ADP-核糖）转移酶催化的组蛋白H1的ADP-核糖基化反应的影响。在所测试的化合物中，ε- Ap4A和ApCH2pppA被证明是该酶最有效的抑制剂。从对其作用的动力学研究来看，ε- Ap4A和ApCH2pppA可能是“混合型”抑制剂。
Zotero 插件