State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.
Chem Commun (Camb). 2019 May 28;55(44):6269-6272. doi: 10.1039/c9cc02345c.
Porphyrin-based covalent organic polymer nanoparticles were synthesized via a Schiff base reaction at room temperature. The resulting product showed a good photodynamic effect and a high photothermal conversion efficiency (34.88%). Both in vitro and in vivo experiments demonstrated the enhanced antitumor efficacy via synergistic photodynamic and photothermal therapy.
基于卟啉的共价有机聚合物纳米粒子是通过室温下的席夫碱反应合成的。所得产物显示出良好的光动力效应和高光热转换效率（34.88%）。体外和体内实验均表明协同光动力和光热治疗增强了抗肿瘤疗效。
