BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, School of Chemistry Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Theranostics. 2022 Jan 31;12(5):2028-2040. doi: 10.7150/thno.68563. eCollection 2022.
: The combination of photosensitizers, oxygen supply agents, and adjuvant therapy drugs in a single nano-drug delivery system for photodynamic therapy (PDT) has been showing great promises to overcome the inherent challenges of PDT for tumor treatment. However, the complicated preparation of integrating multiple components hampers their further developments. Here, we describe a self-assembly nanomicelle with rationally designed building blocks, which shows a high efficiency of synergistic chemo-photodynamic therapy in the animal modal. : The nanomicelle was prepared by a coordination-driven self-assembly based on a rationally designed ferrocene cyclopalladated compound coupled with photosensitizers and hyaluronic acid (referred to as FCP-Tph/HA). The morphology, targeting drug delivery, pharmacokinetics, hemolysis, and multimodal synergistic therapy of FCP-Tph/HA were investigated. : The formation of nanomicelles presents a low hemolysis rate and a prolonged blood circulation time. FCP-Tph/HA possesses an enhanced antitumor effect through the specific binding of HA to CD44 and combining chemotherapy with oxygen self-supplying PDT. Simultaneously, the nanomicelle facilitates a significantly improved antitumor efficacy (>90% tumor regression) on a breast cancer model . : Our results present a modular self-assembled nanomicellar platform with synergistic chemo-photodynamic therapy for challenging PDT-based tumor treatment.
: 光敏剂、氧供剂和辅助治疗药物的组合在单一的光动力治疗（PDT）纳米药物传递系统中，为克服 PDT 治疗肿瘤的固有挑战提供了很大的希望。然而，将多种成分整合到一起的复杂制备过程阻碍了它们的进一步发展。在这里，我们描述了一种具有合理设计的构筑单元的自组装纳米胶束，该胶束在动物模型中表现出高效的协同化学-光动力治疗作用。 : 该纳米胶束是通过基于合理设计的二茂铁环钯配合物与光敏剂和透明质酸（称为 FCP-Tph/HA）的配位驱动自组装制备的。研究了 FCP-Tph/HA 的形态、靶向药物传递、药代动力学、溶血和多模式协同治疗作用。 : 纳米胶束的形成表现出低溶血率和延长的血液循环时间。FCP-Tph/HA 通过 HA 与 CD44 的特异性结合，并结合化疗和自供氧 PDT，具有增强的抗肿瘤作用。同时，纳米胶束显著提高了乳腺癌模型的抗肿瘤疗效（>90%的肿瘤消退）。 : 我们的结果提出了一种具有协同化学-光动力治疗作用的模块化自组装纳米胶束平台，用于治疗基于 PDT 的挑战性肿瘤。
