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内毒素耐受导致单核细胞代谢灵活性丧失:理解脓毒症引起免疫麻痹的模型?

Loss of monocyte metabolic plasticity in endotoxin tolerance: A model for understanding sepsis-induced immune paralysis?

机构信息

Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA.

Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee, 37614, USA.

出版信息

J Leukoc Biol. 2019 Jul;106(1):7-9. doi: 10.1002/JLB.4CE0319-100R. Epub 2019 May 14.

Abstract

Discussion on implications of the immune paralysis that occurs in many sepsis patients.

摘要

探讨许多脓毒症患者中出现的免疫麻痹的影响。

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Endotoxin tolerance: new mechanisms, molecules and clinical significance.内毒素耐受:新机制、分子及临床意义。
Trends Immunol. 2009 Oct;30(10):475-87. doi: 10.1016/j.it.2009.07.009. Epub 2009 Sep 24.

本文引用的文献

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Why have clinical trials in sepsis failed?为什么脓毒症临床试验会失败?
Trends Mol Med. 2014 Apr;20(4):195-203. doi: 10.1016/j.molmed.2014.01.007. Epub 2014 Feb 24.
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Epidemiology of severe sepsis.严重脓毒症的流行病学。
Virulence. 2014 Jan 1;5(1):4-11. doi: 10.4161/viru.27372. Epub 2013 Dec 11.

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