先天免疫 DNA 传感器 cGAS：是膜蛋白、胞质溶胶蛋白还是核蛋白？
The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
机构信息
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University,106 91 Stockholm, Sweden.
The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, 90 187, Umeå, Sweden.
出版信息
Sci Signal. 2019 May 14;12(581):eaax3521. doi: 10.1126/scisignal.aax3521.
Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.
环鸟苷酸-腺苷酸合酶（cGAS）可向细胞内的先天免疫系统发出警报，提示有外来或受损的自身 DNA 的存在，这对于感染、炎症性疾病和癌症的结果至关重要。两项研究现在表明，cGAS 的激活受到其非酶促的 N 端结构域的差异亚细胞定位的调节。
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